Mark at 00:17, 29 May 2014

2014-05-29T00:17:54Z

Mark: Created page with "Protein phosphatases are key components in many signaling pathways. They work together with kinases to regulate most of the signal transduction in eukaryotic cells. By turning..."

2014-03-14T17:51:52Z

Created page with "Protein phosphatases are key components in many signaling pathways. They work together with kinases to regulate most of the signal transduction in eukaryotic cells. By turning..."

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Protein phosphatases are key components in many signaling pathways. They work together with kinases to regulate most of the signal transduction in eukaryotic cells. By turning “on” and “off” the substrate activity, protein phosphatases also control many other cellular processes, such as metabolism, cell cycle progression, cytoskeleton assembly, cell movement, apoptosis, and differentiation. Not surprisingly then, protein phosphatases are involved in many human diseases, such as cancer, Alzheimer’s disease and autoimmunity diseases. In contrast to protein kinases, most of which share a eukaryotic protein kinase (ePK) superfamily catalytic domain, protein phosphatases have catalytic domains from multiple superfamilies with distinct protein folds and catalytic mechanisms.

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		+	== Introduction to Protein Phosphatases ==
	Protein phosphatases are key components in many signaling pathways. They work together with kinases to regulate most of the signal transduction in eukaryotic cells. By turning “on” and “off” the substrate activity, protein phosphatases also control many other cellular processes, such as metabolism, cell cycle progression, cytoskeleton assembly, cell movement, apoptosis, and differentiation. Not surprisingly then, protein phosphatases are involved in many human diseases, such as cancer, Alzheimer’s disease and autoimmunity diseases. In contrast to protein kinases, most of which share a eukaryotic protein kinase (ePK) superfamily catalytic domain, protein phosphatases have catalytic domains from multiple superfamilies with distinct protein folds and catalytic mechanisms.		Protein phosphatases are key components in many signaling pathways. They work together with kinases to regulate most of the signal transduction in eukaryotic cells. By turning “on” and “off” the substrate activity, protein phosphatases also control many other cellular processes, such as metabolism, cell cycle progression, cytoskeleton assembly, cell movement, apoptosis, and differentiation. Not surprisingly then, protein phosphatases are involved in many human diseases, such as cancer, Alzheimer’s disease and autoimmunity diseases. In contrast to protein kinases, most of which share a eukaryotic protein kinase (ePK) superfamily catalytic domain, protein phosphatases have catalytic domains from multiple superfamilies with distinct protein folds and catalytic mechanisms.

Introduction to Phosphatases - Revision history

Mark at 00:17, 29 May 2014

Mark: Created page with "Protein phosphatases are key components in many signaling pathways. They work together with kinases to regulate most of the signal transduction in eukaryotic cells. By turning..."