Main Page - Revision history

Gerard at 16:04, 13 April 2017

2017-04-13T16:04:31Z

2017-04-11T16:13:35Z

2017-04-11T16:13:20Z

2017-04-11T16:11:54Z

2017-04-10T04:44:06Z

2017-04-10T04:33:16Z

‎Technical notes

2017-04-10T04:29:22Z

2017-04-10T04:26:13Z

2017-04-10T04:24:54Z

‎Additional Topics

2017-04-10T04:23:56Z

‎Additional Topics

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 __NOTOC__
-Welcome to Phosphatase Wiki, a resource for phosphatases and phosphatase signaling focused on genomics and evolution. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. Initial content is mostly from the Manning lab at Salk (moved to Genentech in 2012), but we welcome anyone who would like to contribute. Like other wikis, just go to the login page to request an account.
+Welcome to Phosphatase Wiki, a resource for phosphatases and phosphatase signaling focused on genomics and evolution. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. This also includes supporting data and results for our 2017 Science Signaling paper on the genomics and evolution of phosphatases <cite>Chen</cite>.  Initial content is mostly from the Manning lab at Salk (moved to Genentech in 2012), but we welcome anyone who would like to contribute. Like other wikis, just go to the login page to request an account.
 == [[phosphatase classification|Protein Phosphatase Classification and Evolution]] ==
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 ==[[Sandbox]]==

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 __NOTOC__
 Welcome to Phosphatase Wiki, a resource for phosphatases and phosphatase signaling focused on genomics and evolution. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. Initial content is mostly from the Manning lab at Salk (moved to Genentech in 2012), but we welcome anyone who would like to contribute. Like other wikis, just go to the login page to request an account.
 == [[phosphatase classification|Protein Phosphatase Classification and Evolution]] ==

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 In contrast with kinases, there are multiple folds of protein phosphatases, which means protein phosphatases have multiple independent evolutionary origins, while most kinases have a single origin. We classified protein phosphatases into a hierarchy scheme of four levels: fold, superfamily, family and subfamily.
-===== [[Pseudophosphatases|Catalytically inactive phosphatases]] (pseudophosphatases) =====
+===== [[Pseudophosphatases]]  =====
-Protein phosphatases have various functions. Some protein phosphatases lack catalytically activity, but them play critical roles in various cellular signaling pathways.
+Some phosphatases are catalytically inactive, due to alterations in the active site, but are conserved and frequently function in signaling pathways.
 ===== Protein phosphatase evolution =====

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 Welcome to Phosphatase Wiki, a resource for phosphatases and phosphatase signaling focused on genomics and evolution. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. Initial content is mostly from the Manning lab at Salk (moved to Genentech in 2012), but we welcome anyone who would like to contribute. Like other wikis, just go to the login page to request an account.
-== [[Introduction to Phosphatases]] ==
 == [[phosphatase classification|Protein Phosphatase Classification and Evolution]] ==
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 * [[Drug_Targeting_Phosphatases|Phosphatases as drug and/or inhibitor targets]]
 * [[Dephosphorylation_on_unusual_amino_acids|(De)phosphorylation on unusual amino acids]]: unusual evidence for phosphorylation on histidine, aspartate, cysteine, lysine, and arginine.
 == [[Phosphatase_Glossary|Phosphatase Glossary]] ==

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 * [[Dephosphorylation_on_unusual_amino_acids|(De)phosphorylation on unusual amino acids]]: unusual evidence for phosphorylation on histidine, aspartate, cysteine, lysine, and arginine.
-== Glossary ==
+== [[Phosphatase_Glossary|Phosphatase Glossary]] ==
-* [[Phosphatase_Glossary|Miscellaneous]]
-* [[Protein_Domain|Protein domain and motif]]
-* [[Signaling_Pathway_And_Proteins|Signaling pathways and proteins]]
 == [[Technical_Notes|Technical Notes]] ==

← Older revision		Revision as of 04:33, 10 April 2017
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	* [[Signaling_Pathway_And_Proteins\|Signaling pathways and proteins]]		* [[Signaling_Pathway_And_Proteins\|Signaling pathways and proteins]]

−	== [[Technical ~~notes~~]] ==	+	== [[Technical_Notes\|Technical Notes]] ==

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 * [[Signaling_Pathway_And_Proteins|Signaling pathways and proteins]]
-== Technical notes ==
+== [[Technical notes]] ==
-* [[Phosphatome_Computational_Tools_and_Resources|Phosphatome computational tools and resources]]
-* [[Notes_of_Sequenced_Genomes|Notes of Sequenced Genomes]]
-* [[HMM|HMMs]]
-* [[Wiki_Management|Wiki Management]]

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 == [[phosphatase classification|Protein Phosphatase Classification and Evolution]] ==
 This is the heart of this wiki - a set of articles on individual families, subfamilies and folds of phosphatases, with a focus on genomics, evolution, and biological functions shared across organisms.
 ===== [[Phosphatase_classification#Classification_Chart_of_Protein_Phosphatases|Classification chart]] =====
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 ===== [[Human_Protein_Phosphatase_Pseudogene|Human protein phosphatase pseudogenes]] =====
 There are about 80 pseudogenes which originated from the protein-coding genes that encode protein phosphatases in human. They are functional at least in some cases. For instance, PTENP1 is a processed pseudogene of PTEN and regulates PTEN by both sense and antisense RNAs.
 * [[Phosphatases_and_Diseases|Phosphatases and diseases]]