Phosphatase Fold HP - Revision history

Gerard at 21:51, 25 October 2016

2016-10-25T21:51:32Z

Gerard at 18:50, 26 August 2016

2016-08-26T18:50:52Z

Mark at 17:24, 2 June 2015

2015-06-02T17:24:07Z

Gerard at 06:12, 5 January 2015

2015-01-05T06:12:17Z

Gerard at 06:11, 5 January 2015

2015-01-05T06:11:47Z

Gerard at 05:55, 5 January 2015

2015-01-05T05:55:20Z

Mark: /* Families */

2015-01-01T19:23:37Z

‎Families

Mark at 19:23, 1 January 2015

2015-01-01T19:23:18Z

Mark: /* Classification */

2015-01-01T19:22:28Z

‎Classification

Mark: /* Classification */

2015-01-01T19:21:43Z

‎Classification

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]] (histidine phosphatase)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]
 The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase ([http://en.wikipedia.org/wiki/Phosphoglycerate_mutase PGM]) activity. The mutase activity transfers a phosphate within an intermediate of glycolysis. Both activities require a catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>, hence the histidine phosphatase name. For a complete list of functions characterized members in the superfamily see Table 1 and Table S1 in <cite>rigen08</cite>. HPs are found in both prokaryotes and eukaryotes.

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]] (histidine phosphatase)
-The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase ([http://en.wikipedia.org/wiki/Phosphoglycerate_mutase PGM]) activity. The mutase activity transfers a phosphate within an intermediate of glycolysis. Both activities require a catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>, hence the histidine phosphatase name. For a complete of functions characterized members in the superfamily (Table 1 and Table S1 in <cite>rigen08</cite>). HPs are found in both prokaryotes and eukaryotes.
+The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase ([http://en.wikipedia.org/wiki/Phosphoglycerate_mutase PGM]) activity. The mutase activity transfers a phosphate within an intermediate of glycolysis. Both activities require a catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>, hence the histidine phosphatase name. For a complete list of functions characterized members in the superfamily see Table 1 and Table S1 in <cite>rigen08</cite>. HPs are found in both prokaryotes and eukaryotes.
-===== Naming: histidine phosphatase (HP) or phosphoglycerate mutase (PGM) =====
+==== Naming: histidine phosphatase (HP) or phosphoglycerate mutase (PGM) ====
 The earliest and arguably best studied members of this group of genes primarily function as mutates, which results in naming them PGM. However, most if not all of later discoveries have been phosphatase activities of one kind or another <cite>rigden08</cite>. To reflect this fact, we call it histidine phosphatase rather than phosphoglycerate mutase, although the genes are sometimes referred as PGM in the literature and in the SCOP database.
-===== Superfamilies and families =====
+====Superfamilies and families ====
 The fold HP has a single superfamily [[Phosphatase_Superfamily_HP|HP]], which consists of two families based upon sequence similarity <cite>rigden08</cite>:
 * [[Phosphatase_Family_HP1|Branch 1]]
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 This classification is largely the same with [[#Pfam|Pfam]] classification.
-====== Traditional classification ======
+===== Traditional classification =====
 Traditionally, HP/PGM is classified as below <cite>jedrzejas00, rigden01</cite>:
 * Monophosphoglycerate mutase (mPGM) - catalyzes the interconversion of 3-phosphoglycerate (3PGA) and 2-phosphoglycerate (2PGA)
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 * Bisphosphoglycerate mutase (bPGM) - catalyzes primarily the interconversion of 1,3-phosphoglycerate (13PGA) and 23PGA
-====== Pfam ======
+===== Pfam =====
 HP corresponds to [http://pfam.xfam.org/clan/CL0071 histidine phosphatase superfamily] in  [[Phosphatase_Glossary#Pfam|Pfam database]]. It contains two families: [http://pfam.xfam.org/family/PF00300 branch 1] and [http://pfam.xfam.org/family/PF00328 branch 2]. Branch 1 includes dPGMs, branch 2 includes histidine acid phosphatase. Branch 1 is largely dPGM.
-======  SCOP ======
+=====  SCOP =====
 HP corresponds to [[Phosphatase_Glossary#SCOP|SCOP]] fold [http://scop.berkeley.edu/sunid=53253 phosphoglycerate mutase-like (c.60)]. It contains single superfamily, which include the families below:
 * c.60.1.1: Cofactor-dependent phosphoglycerate mutase

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]] (histidine phosphatase)
-The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase ([http://en.wikipedia.org/wiki/Phosphoglycerate_mutase PGM]) activity. The mutase activity transfers a phosphate within an intermediate of glycolysis. Both activities require a catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>, hence the histidine phosphatase name. For a complete of functions characterized members in the superfamily (Table 1 and Table S1 in <cite>rigen08</cite>).
+The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase ([http://en.wikipedia.org/wiki/Phosphoglycerate_mutase PGM]) activity. The mutase activity transfers a phosphate within an intermediate of glycolysis. Both activities require a catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>, hence the histidine phosphatase name. For a complete of functions characterized members in the superfamily (Table 1 and Table S1 in <cite>rigen08</cite>). HPs are found in both prokaryotes and eukaryotes.
 ===== Naming: histidine phosphatase (HP) or phosphoglycerate mutase (PGM) =====

@@ Line 36: / Line 36: @@
 #rigden01 pmid=11514674
 #rigden08 pmid=18092946
 #Rigden pmid=18092946
 </biblio>

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]] (histidine phosphatase)
-The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase (PGM) activity. Histidine phosphatase does '''not''' dephosphorylate pHis. It  is named for the catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>. The superfamily is a large functionally diverse group of proteins. For a complete of functions characterized members in the superfamily (Table 1 and Table S1 in <cite>rigen08</cite>).
+The HP (histidine phosphatase) fold has several enzymatic activities, including phosphatase and phosphoglycerate mutase ([http://en.wikipedia.org/wiki/Phosphoglycerate_mutase PGM]) activity. The mutase activity transfers a phosphate within an intermediate of glycolysis. Both activities require a catalytic histidine which is phosphorylated during catalysis <cite>rigden08</cite>, hence the histidine phosphatase name. For a complete of functions characterized members in the superfamily (Table 1 and Table S1 in <cite>rigen08</cite>).
 ===== Naming: histidine phosphatase (HP) or phosphoglycerate mutase (PGM) =====

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 ===== Families =====
-The fold/superfamily HP  consists of two families based upon sequence similarity <cite>rigden08</cite>:
+The fold HP has a single superfamily [[Phosphatase_Superfamily_HP|HP]], which consists of two families based upon sequence similarity <cite>rigden08</cite>:
 * [[Phosphatase_Family_HP1|Branch 1]]
 * [[Phosphatase_Family_HP2|Branch 2]]