Phosphatase Gene HsapP726 - Revision history

Gerard at 17:25, 22 October 2015

2015-10-22T17:25:37Z

Gerard at 17:13, 22 October 2015

2015-10-22T17:13:31Z

Gerard at 17:12, 22 October 2015

2015-10-22T17:12:01Z

Mark: Created page with "Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corre..."

2015-10-08T17:14:31Z

Created page with "Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corre..."

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Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>.

== References ==
<biblio>
#Liang10 pmid=20112338
</biblio>

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-TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element.
+TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element. It is expressed at ~2 RPKM in a wide variety of tissues (GTEx), and is consistently downregulated in a variety of cancers (TCGA). Bisulfite sequencing indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>. A 15 kD ORF was detected by peptide antibodies, but no function is known.
-−
-Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>. A 15 kD ORF was detected by peptide antibodies.
 == References ==

@@ Line 1: / Line 1: @@
 TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element.
-Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>.
+Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>. A 15 kD ORF was detected by peptide antibodies.
 == References ==

← Older revision		Revision as of 17:12, 22 October 2015
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		+	TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element.
		+
	Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>.		Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>.