Mark: /* Original gene model */

2015-06-25T02:12:50Z

‎Original gene model

Mark: Created page with "=== Sequence version 1.1 === The 1.1 version removes the two additional domains at C-terminal. The domain combination of three domains is not found in other genes, even the cl..."

2015-06-25T01:41:34Z

Created page with "=== Sequence version 1.1 === The 1.1 version removes the two additional domains at C-terminal. The domain combination of three domains is not found in other genes, even the cl..."

New page

=== Sequence version 1.1 ===
The 1.1 version removes the two additional domains at C-terminal. The domain combination of three domains is not found in other genes, even the closest organisms to sponge, by BLASTing the full sequence of 1.0 version against NR database. Thus, it is more possible that the two domains belong to another one or two genes.

The original gene model has a better match (lower E-value), covering the DSPc profile from 1-132. The sequence version 1.0 covers from 39-132. Thus, the original gene model is used as version 1.1.

MPINNQELLKQVHFTGEADCQEFHPHPLRPSLCTDCNKLFSKHEPGAIPNDEALLQALAHSTKAEKTPDRILTTSSGGGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTAVQEARDILKINFLELNWEDTETWLIPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSELLQELRQAIRI

=== Sequence version 1.0 ===
The 1.0 version updates the original gene model with an insertion and two additional domains to the C-terminal: an Adenosine/AMP deaminase domain and a possible lysine decarboxylase.

MPINNQELLKQVHFTGEADCQEFHPHPLRPSLCTDCNKLFSKHEPGAIPNDEALLQALAHSTKAEKTPDRILTTSSGGGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLVGKVYTVSANEIICYDCMISSSQTAVQEARDILKINFLELNWEDTETWLIPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFENNKMADPTQSLLYYIEDIPKAELHIHIEGTLEPELMFKLAERNGIKLEGTVSSHKDRRQTFKNLQDFLDLYYEACSVLKEEEDFFDLMNAYLQKAAHDSVLVAEIFFDPQTHTERGVPFETVINGLHRGLCHGYQHYNIKGSLILCFLRHLSEDEAIKTLKEAMPHLDKIIGVGLDSGEVGNPPEKFEKVFSMARDLGLQVVAHAGEEGGPEYITGALDCLKAKRIDHGVQCLSSDELVSSLVARKIPLTVCPLSNIKLQVASRYFNGASPVKQLLDKGLLVTINSDDPAYFGGYINANFVQAVKDCKLTAKDVFNICRNAFNATFLPLVEKEYYLSCLNRFNVESGFAAPPKSVAIFGSRQPAPGTPQYEMARKLAGMFASRGYQVASGGYNGIMKAASHGANDEGGLSLGVLSPRTFRSRNPIGNEYVSKTMLSLSFSSRTSDLIETSEYLIAFPGKMGTFTEIIVSWSHWVGRSERNYPAKKLYIYREPLGTLFQDVVKRLGVSDAEIEHVILFDSLDEVLEGVERDFEERKKKAVF

=== Original gene model ===
[http://metazoa.ensembl.org/Amphimedon_queenslandica/Transcript/Sequence_Protein?db=core;g=Aqu1.222977;r=Contig13453:17825-19152;t=PAC:15721505 Ensembl Genomes]
MPINNQELLKQVHFTGEADCQEFHPHPLRPSLCTDCNKLFSKHEPGAIPNDEALLQALAH
STKAEKTPDRILTTSSGGGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTAV
QEARDILKINFLELNWEDTETWLIPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRSST
AVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSELLQELRQAIRI

@@ Line 13: / Line 13: @@
 === Original gene model ===
 [http://metazoa.ensembl.org/Amphimedon_queenslandica/Transcript/Sequence_Protein?db=core;g=Aqu1.222977;r=Contig13453:17825-19152;t=PAC:15721505 Ensembl Genomes]
-  MPINNQELLKQVHFTGEADCQEFHPHPLRPSLCTDCNKLFSKHEPGAIPNDEALLQALAH
+  MPINNQELLKQVHFTGEADCQEFHPHPLRPSLCTDCNKLFSKHEPGAIPNDEALLQALAHSTKAEKTPDRILTTSSGGGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTAVQEARDILKINFLELNWEDTETWLIPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSELLQELRQAIRI
-STKAEKTPDRILTTSSGGGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTAV
-QEARDILKINFLELNWEDTETWLIPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRSST
-AVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSELLQELRQAIRI

Phosphatase Sequence AqueP003 AA - Revision history

Mark: /* Original gene model */

Mark: Created page with "=== Sequence version 1.1 === The 1.1 version removes the two additional domains at C-terminal. The domain combination of three domains is not found in other genes, even the cl..."