Phosphatase Subfamily CG42327 - Revision history

Gerard at 02:37, 20 December 2016

2016-12-20T02:37:47Z

Gerard at 01:30, 20 December 2016

2016-12-20T01:30:38Z

Gerard at 01:23, 20 December 2016

2016-12-20T01:23:13Z

Gerard: Created page with "NOTOC Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Su..."

2016-12-20T01:05:43Z

Created page with "__NOTOC__ Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Su..."

New page

__NOTOC__

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_ CG42327 |Subfamily CG42327]]

CG42327 is a receptor PTP found in metazoa, of unknown function and distribution.

===Evolution===
CG42327 is defined by the Drosophila melanogaster CG42327 gene. Clear orthologs exist in most arthropods. Possible orthologs exist in several other metazoa, including Amphimedon

===Domain Structure===
Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain.

===Functions===
Unknown

===References===
<biblio>
#Chang pmid=15232111
#Kokel pmid=9585503
#Marlo pmid=16514605
#Song pmid=18160268
</biblio>

@@ Line 5: / Line 5: @@
 ===Evolution===
-CG42327 is defined by the Drosophila melanogaster CG42327 gene. Clear orthologs exist in most arthropods. Possible orthologs exist in several other metazoa, including Amphimedon (AquePTP-Un-2), Monosiga (MbrePTP-Un-8) and S. purpuratus (SpurPTP-Un-2). The Amphimedon protein also encodes a signal peptide.
+CG42327 is defined by the Drosophila melanogaster CG42327 gene. Clear orthologs exist in most arthropods. Possible orthologs exist in several other metazoa, including Amphimedon (AquePTP-Un-2), Monosiga (MbrePTP-Un-8) and S. purpuratus (SpurPTP-Un-2), as well as other varied metazoa such as Lingula anatina (Lingula anatina) and Crassostrea gigas (XP_011444263.1).
 ===Domain Structure===
-Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain.
+Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain. The signal peptide - TM - phosphatase architecture is also seen in many arthropod orthologs and in Amphimedon AquePTP-Un-2, and the signal peptide is also seen in an alternate isoform of (XP_011669700.1) the S. purpuratus gene, along with it's closest ortholog, Saccoglossus kowalevskii XP_006811223.1. The Monosiga putative ortholog has a PDZ domain C-terminal to the phosphatase domain but not signal peptide or TM region, and it's close orthologs in S. rosetta or Monosiga ovata have the same architecture.
-−
-The putative Monosiga homolog (MbrePTP-Un-8) has a Sec14 upstream of the phosphatase domain, but this is not conserved in choanoflagellate orthologs. It also has a C-terminal PDZ domain which is conserved in both Monosiga ovata and S. rosetta.
 ===Functions===

@@ Line 1: / Line 1: @@
 __NOTOC__
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_ CG42327 |Subfamily CG42327]]
 CG42327 is a receptor PTP found in metazoa, of unknown function and distribution.
@@ Line 11: / Line 10: @@
 Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain.
 ===Functions===

Phosphatase Subfamily CG42327 - Revision history

Gerard at 02:37, 20 December 2016

Gerard at 01:30, 20 December 2016

Gerard at 01:23, 20 December 2016

Gerard: Created page with "__NOTOC__ Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Su..."

Gerard: Created page with "NOTOC Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Su..."