Phosphatase Subfamily DSP11 - Revision history

Gerard at 20:43, 19 December 2016

2016-12-19T20:43:54Z

Gerard at 20:43, 19 December 2016

2016-12-19T20:43:27Z

Gerard: /* Evolution */

2016-09-08T13:31:17Z

‎Evolution

Gerard: /* Domain */

2016-02-10T05:36:48Z

‎Domain

Gerard: /* Function */

2016-02-10T05:35:28Z

‎Function

Gerard: /* Evolution */

2016-02-10T05:34:44Z

‎Evolution

Mark: /* Function */

2015-09-18T00:07:08Z

‎Function

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

2015-02-27T18:38:35Z

Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

New page

__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP11|Subfamily DSP11]]

DSP11 is a metazoan-specific subfamily. Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing.

=== Evolution ===
DSP11 subfamily is found through metazoan ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]).

=== Domain ===
DSP11 has a single domain: phosphatase domain.

=== Function ===
DSP11 is mainly localized to the cell nucleus. It was originally identified as being associated with RNA or ribonucleoprotein complexes. It is therefore called phosphatase that interacts with RNA–ribonucleoprotein complex 1 (PIR1). Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing <cite>Sankhala14</cite>. DSP11 prefers to dephosphorylate RNA than phosphoprotein substrates. Its primary function in vivo is supposed to dephosphorylate RNA 5′-ends <cite>Deshpande99</cite>. This is not surprising given that it is close to another ''atypical'' DSP, RNGTT, RNA guanylyltransferase and 5'-phosphatase. Its function was reviewed in introduction of <cite>Sankhala14</cite> in details.

=== References ===
<biblio>
#Deshpande99 pmid=10347225
#Ho99 pmid=10572165
#Lima99 pmid=10589681
#Sankhala14 pmid=21636784
</biblio>

@@ Line 5: / Line 5: @@
 === Evolution ===
-DSP11 is found throughout metazoa ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]). It is most similar to the other RNA phosphatase, [[Phosphatase_Subfamily_RNGTT|RNGTT]] and only weakly similar to other DSPs.
+DSP11 is found throughout metazoa ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]).
 === Domain ===

@@ Line 5: / Line 5: @@
 === Evolution ===
-DSP11 is found throughout metazoa ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]).
+DSP11 is found throughout metazoa ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]). It is most similar to the other RNA phosphatase, [[Phosphatase_Subfamily_RNGTT|RNGTT]] and only weakly similar to other DSPs.
 === Domain ===

@@ Line 5: / Line 5: @@
 === Evolution ===
-DSP11 subfamily is found through metazoa ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]).
+DSP11 is found throughout metazoa ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]).
 === Domain ===

@@ Line 11: / Line 11: @@
 === Function ===
-Human DUSP11 is mainly localized to the cell nucleus. It was originally identified as being associated with RNA or ribonucleoprotein complexes. It is therefore called  phosphatase that interacts with RNA–ribonucleoprotein complex 1 (PIR1). Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing <cite>Sankhala14</cite>. DSP11 prefers to dephosphorylate RNA than phosphoprotein substrates. Its primary function in vivo is supposed to dephosphorylate RNA 5′-ends <cite>Deshpande99</cite>. This is not surprising given that it is close to another ''atypical'' DSP, RNGTT, RNA guanylyltransferase and 5'-phosphatase. Its function was reviewed in introduction of <cite>Sankhala14</cite> in details.
+Human DUSP11 is mainly localized to the cell nucleus. It was originally identified as being associated with RNA or ribonucleoprotein complexes. It is therefore called  phosphatase that interacts with RNA–ribonucleoprotein complex 1 (PIR1). Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing <cite>Sankhala14</cite>. DSP11 prefers to dephosphorylate RNA than phosphoprotein substrates. Its primary function in vivo is supposed to dephosphorylate RNA 5′-ends <cite>Deshpande99</cite>. This is not surprising given that it is close to another ''atypical'' DSP, RNGTT, (RNA guanylyltransferase and 5'-phosphatase). Its function was reviewed in introduction of <cite>Sankhala14</cite> in details.
 === References ===

@@ Line 8: / Line 8: @@
 === Domain ===
-DSP11 has a single domain: phosphatase domain.
+DSP11 has a single domain, the DSP phosphatase domain. The DSP11 catalytic domain is most closely related to that of [[Phosphatase_Subfamily_RNGTT|RNGTT]], and both domains lack the first beta sheet of the domain.
 === Function ===

Phosphatase Subfamily DSP11 - Revision history

Gerard at 20:43, 19 December 2016

Gerard at 20:43, 19 December 2016

Gerard: /* Evolution */

Gerard: /* Domain */

Gerard: /* Function */

Gerard: /* Evolution */

Mark: /* Function */

Mark: Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."