Phosphatase Subfamily DSP14 - Revision history

Gerard at 23:41, 13 April 2017

2017-04-13T23:41:57Z

Gerard: /* Evolution */

2017-04-13T23:41:03Z

‎Evolution

Gerard at 18:47, 13 March 2017

2017-03-13T18:47:49Z

Gerard at 00:44, 13 May 2015

2015-05-13T00:44:09Z

Gerard at 00:43, 13 May 2015

2015-05-13T00:43:40Z

Gerard at 00:27, 13 May 2015

2015-05-13T00:27:00Z

Mark: /* Function */

2015-03-08T02:37:27Z

‎Function

Mark at 02:36, 8 March 2015

2015-03-08T02:36:20Z

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

2015-03-08T00:25:28Z

Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

New page

__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]]

summary...

=== Evolution ===

=== Domain ===

=== Function ===

=== References ===
<biblio>

</biblio>

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 === References ===
 <biblio>
 #Deng14 pmid=23929653
 #Wu03 pmid=12591617

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 === Evolution ===
-DSP14 emerged in [[eumetazoa]] and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21, and DUSP28 (VHP).
+DSP14 emerged in [[eumetazoa]] and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21, and DUSP28 (VHP) <cite>Chen</cite>.
 === Domain ===

← Older revision		Revision as of 18:47, 13 March 2017
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	DUSP28 (VHP) is widely expressed in different tissues according to RNA-seq data from [http://www.gtexportal.org/home/gene/DUSP28 GTEx], but its function is unknown.		DUSP28 (VHP) is widely expressed in different tissues according to RNA-seq data from [http://www.gtexportal.org/home/gene/DUSP28 GTEx], but its function is unknown.
		+
		+	The single Drosophila member, CG15528, and the 4 C. elegans members have not been characterized.

	=== References ===		=== References ===

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]]
-Eumetazoan-specific subfamily acting on the MAPK cascade.
+Eumetazoan-specific subfamily of MAPK phosphatases.
 === Evolution ===

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]]
-Eumetazoan-specific subfamily acting on MAPK cascade.
+Eumetazoan-specific subfamily acting on the MAPK cascade.
 === Evolution ===
-DSP14 emerged in [[eumetazoa]] and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28.
+DSP14 emerged in [[eumetazoa]] and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21, and DUSP28 (VHP).
 === Domain ===
-DSP14 subfamily has a single phosphatase domain.
+DSP14 consist of a single phosphatase domain.
 === Function ===
-DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its kinase activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation <cite>Zheng13</cite>. DUSP14 is widely expressed in different tissues with highest expression in skin tissues (see [http://www.gtexportal.org/home/gene/DUSP14 GTEx]).
+DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation <cite>Zheng13</cite>. DUSP14 is widely expressed in different tissues with highest expression in skin (see [http://www.gtexportal.org/home/gene/DUSP14 GTEx]).
-DUSP18 interacts with and dephosphorylates SAPK/JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 <cite>Wu06</cite>. USP18 was widely expressed in different tissues as evidenced by RT-PCR <cite>Wu03</cite>. RNA-seq from [http://www.gtexportal.org/home/gene/DUSP18 GTEx] shows a high expression in testis and pituitary, and a low expression in skeleton.
+DUSP18 interacts with and dephosphorylates JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 <cite>Wu06</cite>. DUSP18 was widely expressed in different tissues <cite>Wu03</cite>. RNA-seq from [http://www.gtexportal.org/home/gene/DUSP18 GTEx] shows expression predominantly in testis and pituitary.
-DUSP21 plays an important role in sustaining human hepatocellular carcinoma cell proliferation <cite>Deng14</cite>.
+DUSP21 is almost exclusively expressed in testis, but has been reported as a cancer-testis (CT) antigen and required for survival in a hepatocellular carcinoma cell line by RNAi <cite>Deng14</cite>.
 DUSP28 (VHP) is widely expressed in different tissues according to RNA-seq data from [http://www.gtexportal.org/home/gene/DUSP28 GTEx], but its function is unknown.