Phosphatase Subfamily DSP19 - Revision history

Mark at 03:39, 3 March 2015

2015-03-03T03:39:21Z

Mark at 03:38, 3 March 2015

2015-03-03T03:38:35Z

Mark: Created page with "has a single member in human DUSP19 (SKRP1). It is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data fr..."

2015-03-03T03:25:38Z

Created page with "has a single member in human DUSP19 (SKRP1). It is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data fr..."

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has a single member in human DUSP19 (SKRP1). It is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data from gOrtholog]). DUSP19 appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism by which it regulates this pathway remains controversial.

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 Human DUSP19 (SKRP1) appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism is unclear.
 DUSP19 interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway <cite>Zama02a</cite>. DUSP19 also interacted with the MAPKKK, apoptosis signal-regulating kinase 1 (ASK1), but not with MAP kinase kinase kinase 1 (MEKK1) <cite>Zama02b</cite>
 === References ===
 <biblio>
-#Zama02a pmid= 11959861
+#Zama02a pmid=11959861
-#Zama02b pmid= 11959862
+#Zama02b pmid=11959862
 </biblio>

← Older revision		Revision as of 03:38, 3 March 2015
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−	~~has~~ a ~~single member~~ in ~~human DUSP19 (SKRP1)~~. It is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data from gOrtholog]). DUSP19 appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism ~~by which it regulates this~~ pathway ~~remains controversial~~.	+	__NOTOC__
		+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_DSP\|Family DSP]]: [[Phosphatase_Subfamily_DSP19\|Subfamily DSP19]]
		+
		+	DSP19 is a phosphatase subfamily widely found in eukaryotes but absent from fungi. It functions in the regulation of JNK signaling but the precise molecular mechanism is unclear.
		+
		+	=== Evolution ===
		+	DSP19 subfamily is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data from gOrtholog]).
		+
		+	=== Domain ===
		+	DSP19 has a single domain: phosphatase domain.
		+
		+	=== Function ===
		+	Human DUSP19 (SKRP1) appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism is unclear.
		+	DUSP19 interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway <cite>Zama02a</cite>. DUSP19 also interacted with the MAPKKK, apoptosis signal-regulating kinase 1 (ASK1), but not with MAP kinase kinase kinase 1 (MEKK1) <cite>Zama02b</cite>
		+
		+
		+	=== References ===
		+	<biblio>
		+	#Zama02a pmid= 11959861
		+	#Zama02b pmid= 11959862
		+	</biblio>