Phosphatase Subfamily Dullard - Revision history

Gerard at 05:22, 29 December 2014

2014-12-29T05:22:01Z

Gerard at 05:21, 29 December 2014

2014-12-29T05:21:32Z

Gerard: /* Evolution */

2014-12-29T05:20:52Z

‎Evolution

Gerard at 05:17, 29 December 2014

2014-12-29T05:17:50Z

Gerard at 05:17, 29 December 2014

2014-12-29T05:17:24Z

Gerard at 05:17, 29 December 2014

2014-12-29T05:17:02Z

Gerard: Gerard moved page Dullard to Phosphatase Subfamily Dullard

2014-12-29T05:15:22Z

Gerard moved page Dullard to Phosphatase Subfamily Dullard

Mark: Created page with "==Phosphatase Classification: FCP:Dullard== == Introduction == Dullard, is also known as CTDNEP1 (CTD nuclear en..."

2014-03-14T18:17:23Z

Created page with "==Phosphatase Classification: FCP:Dullard== == Introduction == Dullard, is also known as CTDNEP1 (CTD nuclear en..."

New page

==[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[Dullard]]==

== Introduction ==
Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human <cite>Kim07</cite> (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.

== Substrates and Related Kinases ==
{| border="1" cellpadding="5" cellspacing="0" align="center""
|-
! scope="col" |
! scope="col" | Phosphatase
! scope="col" | Lipin
! scope="col" | Kinase
|-
! scope="row" | Yeast
| Nem1-Spo7 complex || Smp2 || Cdc28/Cdk1
|-
! scope="row" | Mammals
| Dullard (-? complex) || LIPIN || mTOR
|}

Note: i) The kinases are of different families in yeast and mammals, though both of them are conserved from yeast to human. (The tree of the family containing yeast Cdc28 may be wrong is KinBase). ii) Dullard may have a unknown partner.

1. Cdc28/Cdk1 (in yeast). Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7 <cite>SantosRosa05</cite>.

2. mTOR (in mammals). Lipin has multiple phosphorylation sites. Though many kinases may involve in the multisite phosphorylation, mTOR plays an important role <cite>Huffman02</cite>.

== Evolutionary History ==
Dullard is conserved from yeast to human, so is its substrate lipin and the kinases phosphorylating lipin. However, interestingly, the kinases in yeast and mammals are of different families, though both of them are present in yeast and mammals. It is quite interesting that the same molecular function are carried out by different protein families in yeast and mammals.

== Domain Combination ==

== Catalytic activity ==

== Curation notes ==

== References ==

<biblio>
#Kim07 pmid=17420445
#SantosRosa05 pmid=15889145
#Huffman02 pmid=11792863
</biblio>

== Links ==
[http://www.ncbi.nlm.nih.gov/gene/23399 Human Dullard] from NCBI Gene

@@ Line 1: / Line 1: @@
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[Phosphatase_Subfamily_Dullard|Subfamily Dullard]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_Dullard|Subfamily Dullard]]
 __NOTOC__
 Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human <cite>Kim07</cite> (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.

@@ Line 5: / Line 5: @@
 ===Evolution===
-Dullard is conserved from yeast to human, so is its substrate lipin and the kinases phosphorylating lipin. However, interestingly, the kinases in yeast and mammals are of different families, though both of them are present in yeast and mammals. It is quite interesting that the same molecular function are carried out by different protein families in yeast and mammals.
+Dullard is conserved from yeast to human, so is its substrate lipin and the kinases phosphorylating lipin. However, interestingly, the described kinases in yeast and mammals are of different families, though both of them are present in yeast and mammals.
 ===Domain Structure===

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[Phosphatase_Subfamily_Dullard|Subfamily Dullard]]
+__NOTOC__
 Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human <cite>Kim07</cite> (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.

@@ Line 24: / Line 24: @@
 | Dullard (-? complex) || LIPIN || mTOR
 |}
+Notes:
-Note: i) The kinases are of different families in yeast and mammals, though both of them are conserved from yeast to human. (The tree of the family containing yeast Cdc28 may be wrong is KinBase). ii) Dullard may have a unknown partner.
-−
 . Cdc28/Cdk1 (in yeast). Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7 <cite>SantosRosa05</cite>.

@@ Line 3: / Line 3: @@
 Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human <cite>Kim07</cite> (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.
 == Substrates and Related Kinases ==
 {| border="1" cellpadding="5" cellspacing="0" align="center""
 |-
@@ Line 24: / Line 31: @@
 . mTOR (in mammals). Lipin has multiple phosphorylation sites. Though many kinases may involve in the multisite phosphorylation, mTOR plays an important role <cite>Huffman02</cite>.
 ===Catalytic activity===

@@ Line 1: / Line 1: @@
-==[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[Dullard]]==
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[Phosphatase_Subfamily_Dullard|Subfamily Dullard]]
 Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human <cite>Kim07</cite> (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.
@@ Line 26: / Line 25: @@
 . mTOR (in mammals). Lipin has multiple phosphorylation sites. Though many kinases may involve in the multisite phosphorylation, mTOR plays an important role <cite>Huffman02</cite>.
-== Evolutionary History ==
+===Evolution===
 Dullard is conserved from yeast to human, so is its substrate lipin and the kinases phosphorylating lipin. However, interestingly, the kinases in yeast and mammals are of different families, though both of them are present in yeast and mammals. It is quite interesting that the same molecular function are carried out by different protein families in yeast and mammals.
-== Domain Combination ==
+===Domain Structure===
-== Catalytic activity ==
+===Catalytic activity===
-== Curation notes ==
+===Curation notes===
-== References ==
+===References===
-−
 <biblio>
 #Kim07 pmid=17420445
@@ Line 47: / Line 45: @@
-== Links ==
+===Links===
 [http://www.ncbi.nlm.nih.gov/gene/23399 Human Dullard] from NCBI Gene

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