Phosphatase Subfamily FCP1 - Revision history

Gerard at 21:45, 3 April 2017

2017-04-03T21:45:54Z

2017-04-03T21:45:34Z

‎Domain Structure

2017-04-01T03:59:58Z

2015-10-15T21:25:22Z

‎Domain Structure

2015-10-13T15:06:17Z

‎Technical notes

2015-06-29T17:41:52Z

‎Substrates and Related Kinases

2015-06-29T17:41:38Z

2015-06-26T18:33:33Z

2015-06-26T18:29:27Z

‎Domain Structure

2015-06-26T18:15:04Z

← Older revision		Revision as of 21:45, 3 April 2017
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	See [[CTD_Phosphorylation\|Phosphorylation of RNA polymerase II C-terminal domain]].		See [[CTD_Phosphorylation\|Phosphorylation of RNA polymerase II C-terminal domain]].
−
−	~~=== [[Phosphatase_Subfamily_FCP1_Tech_Notes\|Technical notes]] ===~~

	=== References ===		=== References ===

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 ===Domain Structure===
-In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region (FCP1_C) that binds regulatory TFIIF.
+In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region (FCP1_C) that binds regulatory TFIIF. Profile models for this domain fail to find it in nematodes or insects, but HHsearch or multiple alignments with Drosophila and C. elegans proteins show several subregions aligned with human and other FCP1, indicating that the domain is conserved in these species.
-−
-The FCP1_C domain is found widely in deuterosomes (from sea urchin to chordates). It is absent from some proteostomes. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.
 ===Functions===

← Older revision		Revision as of 03:59, 1 April 2017
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HAD\|Fold HAD]]: [[Phosphatase_Superfamily_HAD\|Superfamily HAD]]: [[Phosphatase_Family_FCP\|Family FCP]]: [[Phosphatase_Subfamily_FCP1\|Subfamily FCP1]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HAD\|Fold HAD]]: [[Phosphatase_Superfamily_HAD\|Superfamily HAD]]: [[Phosphatase_Family_FCP\|Family FCP]]: [[Phosphatase_Subfamily_FCP1\|Subfamily FCP1]]

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 In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region (FCP1_C) that binds regulatory TFIIF.
-The FCP1_C domain is found widely in deuterosomes (from sea urchin to chordates). It is absent from most proteostomes, except some individual organisms. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.
+The FCP1_C domain is found widely in deuterosomes (from sea urchin to chordates). It is absent from some proteostomes. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.
 ===Functions===

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 See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].
-=== Technical notes ===
+=== [[Phosphatase_Subfamily_FCP1_Tech_Notes|Technical notes]] ===
-==== FCP1_C domain ====
-In order to find FCP1_C domain phylogenetic distribution among FCP1, we obtained the FCP1 from our [http://resdev.gene.com/gOrtholog/view/cluster/MC0001572/overview internal orthology database], which contains 227 from 183 eukaryotic genomes. We then searched the FCP1_C domain by Pfam web server.
-−
-We also searched the FCP1_C domain region of human FCP1 defined by Pfam against NR dataset limiting to metazoa excluding deuterosomes through NCBI BLAST server. We found no hit has E-value lower than 0.1. We did not find FCP1_C in nematostella sequence in NR dataset, because our updated nematostella sequence is different from the one in NR.
 === References ===

← Older revision		Revision as of 17:41, 29 June 2015
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	FCP1 preferentially hydrolyzes Ser2 in CTD repeats in budding yeast <cite> Kamenski04 </cite> and fission yeast <cite> Schwer15 </cite>.		FCP1 preferentially hydrolyzes Ser2 in CTD repeats in budding yeast <cite> Kamenski04 </cite> and fission yeast <cite> Schwer15 </cite>.

−	~~===== Substrates and Related Kinases =====~~
	See [[CTD_Phosphorylation\|Phosphorylation of RNA polymerase II C-terminal domain]].		See [[CTD_Phosphorylation\|Phosphorylation of RNA polymerase II C-terminal domain]].

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 ===== Substrates and Related Kinases =====
 See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].
 === References ===
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 #Schwer15 pmid=25883047
 </biblio>

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 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_FCP1|Subfamily FCP1]]
@@ Line 11: / Line 9: @@
 In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region (FCP1_C) that binds regulatory TFIIF.
-The FCP1_C region is found widely in deuterosomes (from sea urchin to chordates). It is absent from most proteostomes, except some individual organisms. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.
+The FCP1_C domain is found widely in deuterosomes (from sea urchin to chordates). It is absent from most proteostomes, except some individual organisms. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.
 ===Functions===
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 === Links ===
 [http://www.ncbi.nlm.nih.gov/gene/2221 Human FCP1] from NCBI Gene

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 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_FCP1|Subfamily FCP1]]
-F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast <cite>Kamenski04</cite>.
+F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1 (CTDP1), prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast <cite>Kamenski04</cite>.
 ===Evolution===