Phosphatase Subfamily LHPP - Revision history

Gerard at 05:49, 24 July 2017

2017-07-24T05:49:05Z

Gerard at 05:48, 24 July 2017

2017-07-24T05:48:51Z

Gerard at 23:53, 13 April 2017

2017-04-13T23:53:20Z

Gerard at 23:52, 13 April 2017

2017-04-13T23:52:55Z

Gerard at 20:51, 20 March 2017

2017-03-20T20:51:52Z

Mark at 00:48, 22 March 2015

2015-03-22T00:48:39Z

Mark: /* Evolution */

2015-03-22T00:25:32Z

‎Evolution

Mark: /* Evolution */

2015-03-22T00:20:14Z

‎Evolution

Gerard: /* Domain */

2015-03-21T19:39:48Z

‎Domain

Gerard: /* Function */

2015-03-21T19:37:21Z

‎Function

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]: [[Phosphatase_Subfamily_LHPP|Subfamily LHPP]]
-LHPP is a protein histidine phosphatase, similar to [[Phosphatase_Subfamily_PHP|Subfamily PHP]]
+LHPP is a protein histidine phosphatase, similar to [[Phosphatase_Subfamily_PHP|PHP]]
 === Evolution ===

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]: [[Phosphatase_Subfamily_LHPP|Subfamily LHPP]]
-LHPP is a protein histidine phosphatase.
+LHPP is a protein histidine phosphatase, similar to [[Phosphatase_Subfamily_PHP|Subfamily PHP]]
 === Evolution ===

@@ Line 5: / Line 5: @@
 === Evolution ===
-Two clear subsets of this subfamily are seen across eumetazoa: LHPP (lysine histidine pyrophosphate phosphatase) and HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) <cite>Chen</cite>. Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and sea urchin has an additional HDHD2 pseudogene. A HDHD2 homolog is seen in other holozoa, and very similar genes are seen fungi (but lost in ascomycetes), in a few algae and in both bacteria and archaea.
+Two clear subsets of this subfamily are seen across eumetazoa: LHPP (lysine histidine pyrophosphate phosphatase) and HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2). Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and sea urchin has an additional HDHD2 pseudogene  <cite>Chen</cite>. A HDHD2 homolog is seen in other holozoa, and very similar genes are seen fungi (but lost in ascomycetes), in a few algae and in both bacteria and archaea.
 === Domain ===

@@ Line 5: / Line 5: @@
 === Evolution ===
-Two clear subsets of this subfamily are seen across eumetazoa: LHPP (lysine histidine pyrophosphate phosphatase) and HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2). Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and sea urchin has an additional HDHD2 pseudogene. A HDHD2 homolog is seen in other holozoa, and very similar genes are seen fungi (but lost in ascomycetes), in a few algae and in both bacteria and archaea.
+Two clear subsets of this subfamily are seen across eumetazoa: LHPP (lysine histidine pyrophosphate phosphatase) and HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) <cite>Chen</cite>. Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and sea urchin has an additional HDHD2 pseudogene. A HDHD2 homolog is seen in other holozoa, and very similar genes are seen fungi (but lost in ascomycetes), in a few algae and in both bacteria and archaea.
 === Domain ===
@@ Line 17: / Line 17: @@
 === References ===
 <biblio>
 #Hiraishi pmid=10423531
 </biblio>

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]: [[Phosphatase_Subfamily_LHPP|Subfamily LHPP]]
-LHPP is a protein histidine phosphatase conserved in holozoan.
+LHPP is a protein histidine phosphatase.
 === Evolution ===
-LHPP is found across [[holozoa|holozoan]]. Human has two members of this subfamily, LHPP (lysine histidine pyrophosphate phosphatase) and HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2). Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and sea urchin has an additional HDHD2 degenerated into a pseudogene with frameshift.
+Two clear subsets of this subfamily are seen across eumetazoa: LHPP (lysine histidine pyrophosphate phosphatase) and HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2). Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and sea urchin has an additional HDHD2 pseudogene. A HDHD2 homolog is seen in other holozoa, and very similar genes are seen fungi (but lost in ascomycetes), in a few algae and in both bacteria and archaea.
-−
-Several fungi and oomycetes and a small number of bacteria have genes like HDHD2 in sequence, but it is uncertain whether they are true orthologs of HDHD2.
 === Domain ===
-LHPP proteins consist of a single HAD domain with little flanking sequence.
+LHPP proteins consist of a twin HAD domains, from different subfamilies (Hydrolase_6 and Hydolase_like in Pfam), part of the IIA subfamily of HAD superfamily hydrolases. A number of structure are available from the structural genomics consortium, but have not been analyzed for publication.
 === Function ===
 LHPP from cow was shown to dephosphorylate succinic thiokinase and nucleoside diphosphate kinase autophosphorylated at His residues. LHPP also has activity against free phospho-lysine and phospho-histidine amino acids  <cite>Hiraishi</cite>.
 HDHD2 has not been experimentally studied.
 === References ===

@@ Line 12: / Line 12: @@
 === Function ===
 LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate succinic thiokinase and nucleoside diphosphate kinase autophosphorylated at His residues. LHPP also has activity against free phospho-lysine and phospho-histidine amino acids  <cite>Hiraishi</cite>.
-HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied.
+HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is found in most animals but has not been experimentally studied.
 === References ===