Phosphatase Subfamily MINPP1 - Revision history

Gerard at 15:09, 22 March 2017

2017-03-22T15:09:28Z

2016-10-25T21:51:15Z

2015-06-02T21:39:08Z

‎References

2015-06-02T21:37:41Z

‎Domain

2015-06-02T21:32:48Z

‎Domain

2015-06-02T21:25:47Z

2015-06-02T21:18:04Z

‎Functions

2015-06-02T21:16:42Z

‎Functions

2015-06-02T21:11:36Z

‎Functions

2015-06-02T21:09:53Z

‎Functions

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 === Domain ===
-MINPP1 has a phosphatase domain, N-terminal signal peptide. A C-terminal xDEL has been hypothesized as an ER-retention signal, similar to KDEL <cite>Romano99</cite>. However, the xDEL at the C-terminal is not found in invertebrates or fungi or dictystelium.
+MINPP1 has a phosphatase domain, N-terminal signal peptide. A C-terminal xDEL has been hypothesized as an ER-retention signal, similar to KDEL <cite>Romano99</cite>. However, the xDEL at the C-terminal is found only in vertebrates.
 === Functions ===

← Older revision		Revision as of 21:51, 25 October 2016
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	__NOTOC__		__NOTOC__
−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HP\|Fold HP]]: [[Phosphatase_Superfamily_HP\|Superfamily HP]] ~~(histidine phosphatase)~~: [[Phosphatase_Family_HP2\|Family HP, branch 2]]: [[Phosphatase_Subfamily_MINPP1\|MINPP1]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HP\|Fold HP]]: [[Phosphatase_Superfamily_HP\|Superfamily HP]]: [[Phosphatase_Family_HP2\|Family HP, branch 2]]: [[Phosphatase_Subfamily_MINPP1\|MINPP1]]

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 #cho08 pmid=18413611
 #Gerin14 pmid=24423178
 #Windhorst13 pmid=23186306
 </biblio>

@@ Line 9: / Line 9: @@
 === Domain ===
-MINPP1 has a phosphatase domain, N-terminal signal peptide, and C-terminal ADEL similar to KDEL, the ER-retention signal.
+MINPP1 has a phosphatase domain, N-terminal signal peptide. A C-terminal xDEL has been hypothesized as an ER-retention signal, similar to KDEL <cite>Romano99</cite>. However, the xDEL at the C-terminal is not found in invertebrates or fungi or dictystelium.
 === Functions ===

@@ Line 9: / Line 9: @@
 === Domain ===
-MINPP1 has phosphatase domain and N-terminal signal peptide cleavage site.
+MINPP1 has a phosphatase domain, N-terminal signal peptide, and C-terminal ADEL similar to KDEL, the ER-retention signal.
 === Functions ===

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 === Functions ===
-Human MIPP1 does not display any phosphoglycerate mutase activity. MINPP1 is the only hitherto known InsP6 phosphatase. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) <cite>ali93, chi00</cite>.
+Human MIPP1 does not display any phosphoglycerate mutase activity. MINPP1 is the only hitherto known InsP6 (aka phytate) phosphatase <cite>Windhorst13</cite>. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) <cite>ali93, chi00</cite>.
 Human MIPP1 has biologically significant 2,3-BPG phosphatase activity <cite>cho08</cite>. Dictyostelium Mipp1 also shows 2,3-BPG phosphatase activity ''in vitro'' and ''in vivo'' <cite>cho08</cite>. [[Phosphatase_Subfamily_TIGAR|TIGAR]] of HP2 family also dephosphorylates 2,3-BPG <cite>Gerin14</cite>.

@@ Line 12: / Line 12: @@
 === Functions ===
-Human MINPP1 is the only hitherto known InsP6 phosphatase. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) <cite>ali93, chi00</cite>. MIPP1 does not display any phosphoglycerate mutase activity. Human MIPP1 has biologically significant 2,3-BPG phosphatase activity <cite>cho08</cite>. However, [[Phosphatase_Subfamily_TIGAR|TIGAR]] of HP2 family also dephosphorylates 2,3-BPG <cite>Gerin14</cite>.
+Human MINPP1 is the only hitherto known InsP6 phosphatase. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) <cite>ali93, chi00</cite>. MIPP1 does not display any phosphoglycerate mutase activity.
-Yeast has as many as five MINPP1s, including PHO3, PHO5, PHO11, PHO12 and DIA3. The first four have been known to be involved in phosphate metabolism.
+Human MIPP1 has biologically significant 2,3-BPG phosphatase activity <cite>cho08</cite>. Dictyostelium Mipp1 also shows 2,3-BPG phosphatase activity ''in vitro'' and ''in vivo'' <cite>cho08</cite>. [[Phosphatase_Subfamily_TIGAR|TIGAR]] of HP2 family also dephosphorylates 2,3-BPG <cite>Gerin14</cite>.
-Dictyostelium Mipp1 shows 2,3-BPG phosphatase activity ''in vitro'' and ''in vivo'' <cite>cho08</cite>.
+Yeast has as many as five MINPP1s, including PHO3, PHO5, PHO11, PHO12 and DIA3. The first four have been known to be involved in phosphate metabolism.
 === References ===