Phosphatase Subfamily MTMR10 - Revision history

Gerard at 21:37, 8 September 2016

2016-09-08T21:37:32Z

Gerard: /* Evolution */

2016-09-08T21:17:17Z

‎Evolution

Gerard: /* Evolution */

2016-09-08T21:16:40Z

‎Evolution

Gerard: /* Domain Structure */

2016-09-07T15:43:48Z

‎Domain Structure

Gerard: /* Domain Structure */

2016-09-07T15:38:21Z

‎Domain Structure

Gerard: /* Domain Structure */

2016-09-07T15:37:37Z

‎Domain Structure

Mark at 01:54, 9 December 2015

2015-12-09T01:54:17Z

Mark: /* Domain Structure */

2015-06-27T19:01:40Z

‎Domain Structure

Mark at 22:23, 31 December 2014

2014-12-31T22:23:36Z

Mark: /* Domain Structure */

2014-12-31T22:20:07Z

‎Domain Structure

@@ Line 3: / Line 3: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_MTMR10|Subfamily MTMR10]]
-MTMR10 is a conserved pseudophosphatase in metazoa. Its molecular function is unclear.
+MTMR10 is a metazoan pseudophosphatase that interacts with active myotubularins.
 ===Evolution===
@@ Line 14: / Line 14: @@
 ===Catalytic activity and functions===
-MTMR10 is an inactive phosphatase (pseudophosphatase), but its function is unclear. Other pseudophosphatases within myotubularin family ([[Phosphatase_Subfamily_MTMR5|Subfamily MTMR5]] and [[Phosphatase_Subfamily_MTMR9|Subfamily MTMR9]]) regulate active myotubularins via protein interactions mediated by coiled coils. It interacts with MTM1 and MTMR1 of  [[Phosphatase_Subfamily_MTMR1|MTMR1 subfamily]] <cite>Nandurkar03</cite>.
+MTMR10 and MTM12 interact with MTMR2 <cite>Hein</cite>, and MTMR12 also with MTM1 <cite>Nandurkar03</cite>, both of the [[Phosphatase_Subfamily_MTMR1|MTMR1 subfamily]]. In human, mouse and zebrafish, loss of MTMR12 destabilizes MTM1<cite>Gupta</cite>, and in zebrafish, gives a similar disease phenotype to loss of MTM1. Similar interactions between other subfamilies of active and inactive myotubularins are seen, usually mediated by the coiled-coil interaction domains.
 ===References===
 <biblio>
 #Nandurkar03 pmid=12847286
 </biblio>

@@ Line 6: / Line 6: @@
 ===Evolution===
-MTMR10 is found in most metazoa. Humans have 3 genes: MTMR10, MTMR11, MTMR12.
+MTMR10 is found in most metazoa. Humans have 3 genes: MTMR10, MTMR11, MTMR12, and most invertebrates have one.
 ===Domain Structure===

@@ Line 6: / Line 6: @@
 ===Evolution===
-MTMR10 is found in most metazoa.
+MTMR10 is found in most metazoa. Humans have 3 genes: MTMR10, MTMR11, MTMR12.
 ===Domain Structure===

@@ Line 11: / Line 11: @@
 MTMR10 subfamily has three domains: [http://pfam.xfam.org/family/PF02893.15 GRAM], phosphatase domain and coiled-coil domain. The GRAM domain is similar in structure to the PH domain and is found in membrane-associated proteins.
-Sponge has three MTMR10s. Two of them have a [http://pfam.xfam.org/family/PF00531.17 Death domain] and a [http://pfam.xfam.org/family/PF12128.3 DUF3584 domain]. Death domains bind each other forming oligomers. DUF3584 is close to AAA+ superfamily. However, the domain combination is dubious, because it is not found in other organisms.
+Two of the three sponge MTMR10s have a [http://pfam.xfam.org/family/PF00531.17 Death domain] and a [http://pfam.xfam.org/family/PF12128.3 DUF3584 domain] flanking the phosphatase domains. Death domains bind each other forming oligomers. DUF3584 is close to AAA+ superfamily. They do not have a GRAM or coiled-coil domain. The third sponge member is a fragment copy of one of the other two.
 ===Catalytic activity and functions===

@@ Line 11: / Line 11: @@
 MTMR10 subfamily has three domains: [http://pfam.xfam.org/family/PF02893.15 GRAM], phosphatase domain and coiled-coil domain. The GRAM domain is similar in structure to the PH domain and is found in membrane-associated proteins.
-Sponge has three MTMR10s. Two of them have [http://pfam.xfam.org/family/PF00531.17 Death domain] and [http://pfam.xfam.org/family/PF12128.3 DUF3584 domain]. Death domain binds each other forming oligomers. DUF3584 is close to AAA+ superfamily. However, the domain combination is dubious, because it is not found in other organisms.
+Sponge has three MTMR10s. Two of them have a [http://pfam.xfam.org/family/PF00531.17 Death domain] and a [http://pfam.xfam.org/family/PF12128.3 DUF3584 domain]. Death domains bind each other forming oligomers. DUF3584 is close to AAA+ superfamily. However, the domain combination is dubious, because it is not found in other organisms.
 ===Catalytic activity and functions===

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|FoldCC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_MTMR10|Subfamily MTMR10]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_MTMR10|Subfamily MTMR10]]
 MTMR10 is a conserved pseudophosphatase in metazoan. Its molecular function is unclear.