Phosphatase Subfamily MTMR3 - Revision history

Gerard: /* Domain Structure */

2016-09-09T13:39:50Z

‎Domain Structure

2016-09-08T23:05:11Z

‎Mammal MTMR4

2016-03-09T06:10:16Z

‎Evolution

2015-09-15T18:46:41Z

2014-12-31T22:23:00Z

2014-12-30T21:28:32Z

2014-12-30T21:26:26Z

‎Evolution

2014-12-30T20:49:48Z

2014-12-30T20:36:11Z

‎Catalytic activity and functions

2014-12-30T20:07:50Z

‎References

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 ===Domain Structure===
-MTMR3 subfamily has a conserved domain combination: a divergent PH/GRAM domain, an active phosphatase domain and an atypical [http://pfam.xfam.org/family/PF01363.16 FYVE domain]. It has been shown that the FYVE domain of MTMR3 is atypical in that it neither confers endosomal localisation nor binds to the lipid PtdIns3P. Furthermore it is not required for in vitro enzyme activity of MTMR3. In contrast, the PH/GRAM domain is able to bind to phosphoinositide lipids <cite>Lorenzo05</cite>.
+The MTMR3 subfamily has a conserved domain combination: a divergent PH/GRAM domain, an active phosphatase domain and an atypical [http://pfam.xfam.org/family/PF01363.16 FYVE domain]. It has been shown that the FYVE domain of MTMR3 is atypical in that it neither confers endosomal localisation nor binds to the lipid PtdIns3P. Furthermore it is not required for in vitro enzyme activity of MTMR3. In contrast, the PH/GRAM domain is able to bind to phosphoinositide lipids <cite>Lorenzo05</cite>.
 ===Catalytic activity and functions===

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 ==== Mammal MTMR4 ====
-Human MTMR4 is also an inositol lipid 3-phosphatase, with amino acid sequence identity about ~47% <cite>zhao01</cite>. More recently, human MTMR4 has been reported to dephosphorylate [http://en.wikipedia.org/wiki/R-SMAD receptor-regulated SMAD] proteins <cite>yu10, yu13</cite>.  Ectopic expression of human MTMR4 or ''Drosophila'' CG3632, the single member of MTMR3 subfamily in fruit fly, genetically interacted with Bone morphogenetic proteins (BMP) signaling axis in regulation of the vein development of ''Drosophila'' wings <cite>yu13</cite>.
+Human MTMR4 is also an inositol lipid 3-phosphatase, with amino acid sequence identity about ~47% <cite>zhao01</cite>. More recently, human MTMR4 has been reported to dephosphorylate [http://en.wikipedia.org/wiki/R-SMAD receptor-regulated SMAD] proteins <cite>yu10, yu13</cite>.  Ectopic expression of human MTMR4 or the single ''Drosophila'' MTMR3, CG3632, genetically interacted with Bone morphogenetic proteins (BMP) signaling axis in regulation of the vein development of ''Drosophila'' wings <cite>yu13</cite>.
 ===Related Kinases===

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 ===Evolution===
-MTMR3 is in metazoan. It consists of two members in human, MTMR3 and MTMR4. In fruit fly and C elegans, a single copy is found.
+MTMR3 is a metazoan phosphatase, with two human members (MTMR3 and MTMR4) and single copies in Drosophila and C. elegans.
 ===Domain Structure===

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 ===Catalytic activity and functions===
-Human MTMR3 is an inositol lipid 3-phosphatase, with a so-far-unique substrate specificity. It is able to hydrolyze PtdIns3P and PtdIns(3,5)P2, both in vitro and when heterologously expressed in ''S. cerevisiae''. Thus, MTMR3 plays critical role in the cellular production of PtdIns5P <cite>walker01</cite>. Human MTMR4 is also an inositol lipid 3-phosphatase, with amino acid sequence identity about ~47% <cite>zhao01</cite>.
+==== Mammal MTMR3 ====
-More recently, human MTMR4 has been reported to dephosphorylate [http://en.wikipedia.org/wiki/R-SMAD receptor-regulated SMAD] proteins <cite>yu10, yu13</cite>.  Ectopic expression of human MTMR4 or ''Drosophila'' CG3632, the single member of MTMR3 subfamily in fruit fly, genetically interacted with Bone morphogenetic proteins (BMP) signaling axis in regulation of the vein development of ''Drosophila'' wings <cite>yu13</cite>.
+MTMR3 risk polymorphism (rs713875), associated with Inflammatory bowel disease (IBD), increases MTMR3 expression, enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation <cite> Lahiri15 </cite>.
 ===Related Kinases===
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 ===References===
 <biblio>
 #Lorenzo05 pmid=15840652
 #walker01 pmid=11676921

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|FoldCC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_MTMR3|Subfamily MTMR3]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_MTMR3|Subfamily MTMR3]]
 MTMR3 is an inositol lipid 3-phosphatase. It is probably a protein phosphatase of receptor-regulated SMAD.

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 #walker01 pmid=11676921
 #zhao01 pmid=11302699
 </biblio>