Phosphatase Subfamily PAPL - Revision history

Gerard at 01:16, 26 October 2016

2016-10-26T01:16:12Z

Gerard at 01:15, 26 October 2016

2016-10-26T01:15:23Z

Gerard at 01:12, 26 October 2016

2016-10-26T01:12:14Z

Gerard at 01:06, 26 October 2016

2016-10-26T01:06:52Z

Gerard at 01:07, 9 May 2016

2016-05-09T01:07:00Z

Mark at 17:15, 18 June 2015

2015-06-18T17:15:06Z

Mark: /* Evolution */

2015-05-26T14:29:36Z

‎Evolution

Mark: /* Evolution */

2015-05-26T14:28:52Z

‎Evolution

Mark: /* Evolution */

2015-05-13T18:21:54Z

‎Evolution

Mark at 18:20, 13 May 2015

2015-05-13T18:20:49Z

← Older revision		Revision as of 01:16, 26 October 2016
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL\|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL\|Superfamily PPPL]]: [[Phosphatase_Family_PAP\|Family PAP]]: [[Phosphatase_Subfamily_PAPL\|PAPL]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL\|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL\|Superfamily PPPL]]: [[Phosphatase_Family_PAP\|Family PAP]]: [[Phosphatase_Subfamily_PAPL\|PAPL]]

← Older revision		Revision as of 01:15, 26 October 2016
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	=== Function ===		=== Function ===
	PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins. The structural similarity between PAPL and ACP5 has been explored <cite>Flanagan</cite>.		PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins. The structural similarity between PAPL and ACP5 has been explored <cite>Flanagan</cite>.
		+
		+	===References===
		+	<biblio>
		+	#Flanagan pmid=16793224
		+	</biblio>

← Older revision		Revision as of 01:12, 26 October 2016
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	=== Function ===		=== Function ===
−	PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins.	+	PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins. The structural similarity between PAPL and ACP5 has been explored <cite>Flanagan</cite>.

← Older revision		Revision as of 01:06, 26 October 2016
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	=== Function ===		=== Function ===
−	~~Unclear~~.	+	PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins.

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 === Evolution ===
-PAPL subfamily is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members, which probably emerged via different evolutionary events (see below). Each of sea urchin, nematostella, sponge and monosiga has three members, but there is no evidence that supports they belong to any double-conserved synteny by i) browsing [http://www.genomicus.biologie.ens.fr/genomicus-metazoa-25.01/cgi-bin/phyloview.pl?root=1004984&amp;id=1005002&amp;xhide=2:41:9:59:1:55:29:24:25:45:27:42:13:4:58:-1004984:49:56:7:33:38:51&amp;xcollapse=-1004984&amp; Genomicus], and ii) searching the genes in genome browsers (sea urchin in UCSC genome browser, another three in JGI genome browser). The sponge copies arrange as a tandem of three PAPLs, while the copies locate in different scaffolds in sea urchin, nematostella and monosiga. In sum, the multiple copies arose through different duplication events.
+PAPL is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL (aka ACP7, PAPL1), but many invertebrates have multiple members, including 3 members each in Monosiga, Nematostella, sponge, and sea urchin. These appear to be independent expansions by protein sequence similarity, and in sea urchin, they form a tandem duplication cluster.
 === Domain Structure ===
-PAPL has a phosphatase domain and a signal peptide cleavage site on N-terminus. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).
+PAPL has a phosphatase domain and most members have an N-terminal signal peptide cleavage site. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).
 === Function ===
 Unclear.

← Older revision		Revision as of 17:15, 18 June 2015
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[~~Phosphatase_Fold_MTDP~~\|Fold ~~MTDP~~]]:[[~~Phosphatase_Superfamily_MTDP~~\|Superfamily ~~MTDP~~]]: [[Phosphatase_Family_PAP\|Family PAP]]: [[Phosphatase_Subfamily_PAPL\|PAPL]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL\|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL\|Superfamily PPPL]]: [[Phosphatase_Family_PAP\|Family PAP]]: [[Phosphatase_Subfamily_PAPL\|PAPL]]

	=== Evolution ===		=== Evolution ===

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]:[[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PAP|Family PAP]]: [[Phosphatase_Subfamily_PAPL|PAPL]]
 === Evolution ===
-PAPL subfamily is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members. Each of sea urchin, nematostella, sponge and monosiga has three members, but there is no evidence that supports they belong to any double-conserved synteny (see [http://www.genomicus.biologie.ens.fr/genomicus-metazoa-25.01/cgi-bin/phyloview.pl?root=1004984&amp;id=1005002&amp;xhide=2:41:9:59:1:55:29:24:25:45:27:42:13:4:58:-1004984:49:56:7:33:38:51&amp;xcollapse=-1004984&amp; Genomicus] and/or search the genes in genome browsers). The sponge copies arrange as a tandem of three PAPLs, while the copies locate in different scaffolds in sea urchin, nematostella and monosiga.
+PAPL subfamily is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members. Each of sea urchin, nematostella, sponge and monosiga has three members, but there is no evidence that supports they belong to any double-conserved synteny (see [http://www.genomicus.biologie.ens.fr/genomicus-metazoa-25.01/cgi-bin/phyloview.pl?root=1004984&amp;id=1005002&amp;xhide=2:41:9:59:1:55:29:24:25:45:27:42:13:4:58:-1004984:49:56:7:33:38:51&amp;xcollapse=-1004984&amp; Genomicus] and/or search the genes in genome browsers). The sponge copies arrange as a tandem of three PAPLs, while the copies locate in different scaffolds in sea urchin, nematostella and monosiga. In sum, the multiple copies arose through different duplication events.
 === Domain Structure ===