Phosphatase Subfamily PPIP5K - Revision history

Gerard: /* Domain */

2017-04-12T18:04:55Z

‎Domain

2017-04-12T18:03:40Z

‎Domain

2016-10-25T21:51:05Z

2015-10-06T20:01:57Z

‎Domain

2015-05-31T18:58:11Z

2015-05-31T18:49:34Z

2015-05-30T19:44:19Z

2015-05-30T19:43:52Z

2015-01-08T18:28:52Z

2015-01-07T03:41:52Z

‎References

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 PPIP5K has two domains: N-terminal RimK/ATP-grasp kinase domain, and C-terminal HP2 phosphatase domain <cite>fridy07</cite>.  The RimK is the active kinase domain <cite>fridy07, choi07</cite>.
-Unlike other HP2 subfamilies which are protein or non-protein phosphatases, the HP2 domain of PPIP5K is not catalytically active. Instead, this HP2 domain is specialized for binding PtdIns(3,4,5)P3, as a partial PH (pleckstrin homology) consensus sequence is spliced into this HP2 domain <cite>gokhale11</cite>. The HP2 domains of PPIP5Ks are longer than those of other HP2 subfamilies, due to the insertions at multiple sites.
+Unlike other HP2 subfamilies which are protein or non-protein phosphatases, the HP2 domain of PPIP5K is not catalytically active. Instead, it binds PtdIns(3,4,5)P3, in part using an inserted partial PH (pleckstrin homology) domain <cite>gokhale11</cite>. The HP2 domains of PPIP5Ks are longer than those of other HP2 subfamilies, due to insertions at multiple sites.
 === Catalytic activity and functions ===

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 === Domain ===
-PPIP5K has two domains: N-terminal RimK/ATP-grasp domain, and C-terminal HP2 domain <cite>fridy07</cite>.  The RimK is the active kinase domain <cite>fridy07, choi07</cite>.
+PPIP5K has two domains: N-terminal RimK/ATP-grasp kinase domain, and C-terminal HP2 phosphatase domain <cite>fridy07</cite>.  The RimK is the active kinase domain <cite>fridy07, choi07</cite>.
 Unlike other HP2 subfamilies which are protein or non-protein phosphatases, the HP2 domain of PPIP5K is not catalytically active. Instead, this HP2 domain is specialized for binding PtdIns(3,4,5)P3, as a partial PH (pleckstrin homology) consensus sequence is spliced into this HP2 domain <cite>gokhale11</cite>. The HP2 domains of PPIP5Ks are longer than those of other HP2 subfamilies, due to the insertions at multiple sites.

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2]] (HP2): [[Phosphatase_Subfamily_PPIP5K|Subfamily PPIP5K]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]]: [[Phosphatase_Family_HP2|Family HP, branch 2]] (HP2): [[Phosphatase_Subfamily_PPIP5K|Subfamily PPIP5K]]
 PPIP5K is a phosphoinositol kinase that also has a pseudophosphatase domain which binds to PtdIns(3,4,5)P3. PPIP5K converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8.

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 PPIP5K has two domains: N-terminal RimK/ATP-grasp domain, and C-terminal HP2 domain <cite>fridy07</cite>.  The RimK is the active kinase domain <cite>fridy07, choi07</cite>.
-Unlike other HP2 subfamilies which are protein or non-protein phosphatases, the HP2 domain of PPIP5K is not catalytically active. Instead, this HP2 domain is specialized for binding PtdIns(3,4,5)P3, as a partial PH (pleckstrin homology) consensus sequence is spliced into this HP2 domain <cite>gokhale11</cite>.
+Unlike other HP2 subfamilies which are protein or non-protein phosphatases, the HP2 domain of PPIP5K is not catalytically active. Instead, this HP2 domain is specialized for binding PtdIns(3,4,5)P3, as a partial PH (pleckstrin homology) consensus sequence is spliced into this HP2 domain <cite>gokhale11</cite>. The HP2 domains of PPIP5Ks are longer than those of other HP2 subfamilies, due to the insertions at multiple sites.
 === Catalytic activity and functions ===

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 === Evolution ===
-PPIP5K is found in most eukaryotes except for some excavates. Most vertebrates have at least two copies, while invertebrates usually have one.
+PPIP5K is found in most eukaryotes, but is missing in alveolates. Most vertebrates have at least two copies, while invertebrates usually have one.
 === Domain ===

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2]]: [[Phosphatase_Subfamily_PPIP5K|PPIP5K]]
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 === Evolution ===
-PPIP5K is found in most eukaryotes. Most vertebrates have at least two copies, while invertebrates usually have one.
+PPIP5K is found in most eukaryotes except for some excavate. Most vertebrates have at least two copies, while invertebrates usually have one.
 === Domain ===

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 === Catalytic activity and functions ===
 === References ===
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 #choi07 pmid=17702752
 #gokhale11 pmid=21222653
 </biblio>