Phosphatase Subfamily PPM1E - Revision history

Gerard at 01:42, 11 November 2016

2016-11-11T01:42:08Z

Mark at 17:19, 10 June 2015

2015-06-10T17:19:15Z

Mark at 16:46, 10 June 2015

2015-06-10T16:46:36Z

Mark at 16:46, 10 June 2015

2015-06-10T16:46:14Z

Mark at 04:27, 6 May 2014

2014-05-06T04:27:39Z

Mark at 04:20, 6 May 2014

2014-05-06T04:20:09Z

Mark at 04:16, 6 May 2014

2014-05-06T04:16:23Z

Mark: Created page with "Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Phosphatase_..."

2014-05-06T04:13:41Z

Created page with "Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Phosphatase_..."

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]]

PPM1E/F named after two human PPMs, [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g and PAK, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).

← Older revision		Revision as of 01:42, 11 November 2016
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM\|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM\|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E\|Subfamily PPM1E]] (POXP, FEM-2)		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM\|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM\|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E\|Subfamily PPM1E]] (POXP, FEM-2)

@@ Line 2: / Line 2: @@
 === Evolution ===
-CAMK2
+The PPM1E subfamily emerged in holozoa. Its substrates emerged earlier or at the same time: human CAMK1 and CAMK4 belong to CAMK1 kinase subfamily which is found throughout eukaryotes; human CAMK2 belong to CAMK2 subfamily which emerged in holozoa ; human PAK belongs to PAKA subfamily which is common in eukaryotes.
 === Domain ===
 === Functions ===

← Older revision		Revision as of 16:46, 10 June 2015
Line 1:		Line 1:
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM\|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM\|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E\|Subfamily PPM1E]] (POXP, FEM-2)		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM\|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM\|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E\|Subfamily PPM1E]] (POXP, FEM-2)
−
−	The subfamily is named named after two human PPMs, [[Phosphatase_Gene_PPM1E\|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F\|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g <cite>Takeuchi01 Takeuchi04 Ishida05</cite> and PAK <cite>Koh02</cite>, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
−
−	~~The subfamily has some potent inhibitors <cite>Ishida07</cite>.~~
−
−	~~The subfamily also dephosphorylate 5'-AMP-activated protein kinase (AMPK) <cite>Voss12</cite>. The activation of AMPK is related to the treatment of type 2 diabetes.~~

	=== Evolution ===		=== Evolution ===

@@ Line 1: / Line 1: @@
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]] (POXP, FEM-2)
 The subfamily is named named after two human PPMs, [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g <cite>Takeuchi01 Takeuchi04 Ishida05</cite> and PAK <cite>Koh02</cite>, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
@@ Line 7: / Line 7: @@
 The subfamily also dephosphorylate 5'-AMP-activated protein kinase (AMPK) <cite>Voss12</cite>. The activation of AMPK is related to the treatment of type 2 diabetes.
-== References ==
+=== Domain ===
 <biblio>
 #Koh02 pmid=11864573
-#Ishida07 pmid=17897624
+#Ishida98 pmid=9442023
 #Ishida05 pmid=15680915
-#Takeuchi04 pmid=15496589
+#Ishida07 pmid=17897624
 #Takeuchi01 pmid=11726284
 #Voss12 pmid=20801214
 </biblio>

@@ Line 4: / Line 4: @@
 The subfamily has some potent inhibitors <cite>Ishida07</cite>.
@@ Line 13: / Line 15: @@
 #Takeuchi04 pmid=15496589
 #Takeuchi01 pmid=11726284
 </biblio>

← Older revision		Revision as of 04:16, 6 May 2014
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	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM\|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM\|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E\|Subfamily PPM1E]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM\|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM\|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E\|Subfamily PPM1E]]

−	~~PPM1E/F~~ named after two human PPMs, [[Phosphatase_Gene_PPM1E\|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F\|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g and PAK, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).	+	The subfamily is named named after two human PPMs, [[Phosphatase_Gene_PPM1E\|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F\|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g and PAK, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
		+
		+	The subfamily has some potent inhibitors <cite>Ishida07</cite>.
		+
		+
		+	== References ==
		+	<biblio>
		+	#Ishida07 pmid=17897624
		+	#Ishida05 pmid=15680915
		+	#Takeuchi2014 pmid=15496589
		+	</biblio>