Phosphatase Subfamily PPM1K - Revision history

Gerard: /* Functions */

2017-07-25T07:59:07Z

‎Functions

Gerard at 00:39, 4 March 2017

2017-03-04T00:39:35Z

Gerard at 00:39, 4 March 2017

2017-03-04T00:39:09Z

Gerard at 00:28, 4 March 2017

2017-03-04T00:28:53Z

Mark at 19:14, 5 June 2015

2015-06-05T19:14:05Z

Mark: Created page with "Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Phosphatase_Fami..."

2015-06-05T17:59:04Z

Created page with "Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Phosphatase_Fami..."

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ)

=== Evolution ===

=== Domain ===

=== Functions ===

=== References ===

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 === Functions ===
-Human PPM1K is widely expressed in different tissues, most abundant in heart <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database]. Human PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex <cite>Joshi07</cite>.
+PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase (BCKD) complex <cite>Joshi07</cite>. Its loss in Ecdysozoa parallels the loss of the opposing [http://kinase.com/wiki/index.php/Kinase_Family_PDHK BCKDK] kinase. Human PPM1K is widely expressed in different tissues, most abundant in heart <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database].
 === References ===

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM]]: [[Phosphatase_Family_PPM|Family PPM]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP)
 PPM1K is a mitochondrial phosphatase that regulates the membrane permeability transition pore and is part of the BCKDA complex.

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 __NOTOC__
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP)
 === Evolution ===

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 === Evolution ===
-The PPM1K subfamily probably emerged in [[Phosphatase_Glossary#Holozoa|holozoa]]. It was lost in [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]] and sponge. Monosiga brevicollis PPM1K has accessory EF-hand domains at C-terminal.
+The PPM1K subfamily emerged in [[Phosphatase_Glossary#Holozoa|holozoa]]. It was lost in [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]] and sponge. PPM1K is most similar to the ER-anchored phosphatase subfamily [[Phosphatase_Subfamily_PPM1L|PPM1L]].
 === Domain ===
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 === Functions ===
-Human PPM1K is widely expressed in different tissues, most abundant in heart as shown in <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database]. Human PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex <cite>Joshi07</cite>.
+Human PPM1K is widely expressed in different tissues, most abundant in heart <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database]. Human PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex <cite>Joshi07</cite>.
 === References ===
 <biblio>