Phosphatase Subfamily PPM1Z - Revision history

Gerard: /* Evolution */

2017-03-24T16:04:54Z

‎Evolution

Gerard: /* Functions */

2017-03-04T21:39:31Z

‎Functions

Gerard: /* Evolution */

2017-03-04T21:38:39Z

‎Evolution

Gerard: /* Domain */

2016-11-11T06:31:36Z

‎Domain

Gerard at 06:22, 11 November 2016

2016-11-11T06:22:15Z

Gerard: /* Evolution */

2016-11-11T04:38:31Z

‎Evolution

Gerard: /* Evolution */

2016-11-11T01:51:44Z

‎Evolution

Mark: Mark moved page Phosphatase Subfamily PTC2 to Phosphatase Subfamily PPM1Z

2015-06-08T20:47:10Z

Mark moved page Phosphatase Subfamily PTC2 to Phosphatase Subfamily PPM1Z

Mark at 20:47, 8 June 2015

2015-06-08T20:47:00Z

Mark at 20:16, 8 June 2015

2015-06-08T20:16:44Z

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 === Evolution ===
-The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to [[Phosphatase_Subfamily_PPM1G|PPM1G]], but it lacks the characteristic PPM1G acidic domain inserted into phosphatase domain. It is also similar to [[Phosphatase_Subfamily_PPM1A|PPM1A]], and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies. Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 an unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does define it as a PPM1Z.
+The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to [[Phosphatase_Subfamily_PPM1G|PPM1G]], but it lacks the characteristic PPM1G acidic insert in the phosphatase domain. It is also similar to [[Phosphatase_Subfamily_PPM1A|PPM1A]], and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies. Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 an unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does define it as a PPM1Z.
 === Domain ===

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 === Functions ===
 The function of PPM1Z is unclear.
-Drosophila has two members, CG17746 and PPM1, which is a likely retrogene copy of GC17746 <cite>Diaz-Castillo</cite>. CG17746 interacts with both actin (Act5C) and myosin (sqh) <cite>Guruharsha</cite>, and a number of other genes involved in cell cycle or replication. CG17746 and one of it's interactors, CG8128 (a nudix hydrolase) were both found to suppress pink1-induced mitochondrial fusion <cite>Pogson</cite>, along with several other phosphatases and kinases. The C. elegans PP1Z, ppm-2, binds the ubiquitin ligase RPM-1, and regulates axonal outgrowth through dephosphorylation of the dlk-1 kinase <cite>Baker</cite>. dlk-1 is a JNK kinase, and Drosophila CG17746 was also reported as an enhancer of JNK signaling <cite>Bakal</cite>, giving a first hint of a cross-species role in DLK-JNK signaling.
+Drosophila has two members, CG17746 and PPM1, which is a likely retrogene copy of GC17746 <cite>Diaz-Castillo</cite>. CG17746 interacts with both actin (Act5C) and myosin (sqh) <cite>Guruharsha</cite>, and a number of other genes involved in cell cycle or replication. CG17746 and one of its interactors, CG8128 (a nudix hydrolase) were both found to suppress pink1-induced mitochondrial fusion <cite>Pogson</cite>, along with several other phosphatases and kinases. The C. elegans PP1Z, ppm-2, binds the ubiquitin ligase RPM-1, and regulates axonal outgrowth through dephosphorylation of the dlk-1 kinase <cite>Baker</cite>. dlk-1 is a JNK kinase, and Drosophila CG17746 was also reported as an enhancer of JNK signaling <cite>Bakal</cite>, giving a first hint of a cross-species role in DLK-JNK signaling.
 === References ===

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 === Evolution ===
-The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to [[Phosphatase_Subfamily_PPM1G|PPM1G]], but it lacks the characteristic PPM1G acidic domain inserted into phosphatase domain. It is also similar to [[Phosphatase_Subfamily_PPM1A|PPM1A]], and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies.
+The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to [[Phosphatase_Subfamily_PPM1G|PPM1G]], but it lacks the characteristic PPM1G acidic domain inserted into phosphatase domain. It is also similar to [[Phosphatase_Subfamily_PPM1A|PPM1A]], and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies. Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 an unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does define it as a PPM1Z.
-−
-Notice: Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 an unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z.
 === Domain ===

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 === Domain ===
-The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.
+The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily. C. elegans ppm-2 was shown to be myristoylated and that myristoylation was required for full function <cite>Baker</cite>
-−
 === Functions ===
 The function of PPM1Z is unclear.

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 === Domain ===
 The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.
-−
 === Functions ===
 The function of PPM1Z is unclear.
 === References ===
 <biblio>
 </biblio>

← Older revision	Revision as of 20:47, 8 June 2015
(No difference)

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PTC2|Subfamily PTC2]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1Z|Subfamily PPM1Z]]
-−
- Notice: '''The page is obsoleted. The subfamily is merged with [[Phosphatase_Subfamily_PPM1A|PPM1A subfamily]].'''
 === Evolution ===