Phosphatase Subfamily PPP1C - Revision history

Gerard at 17:32, 13 March 2017

2017-03-13T17:32:24Z

Gerard: /* Functions */

2016-09-07T18:42:23Z

‎Functions

Mark at 21:46, 14 September 2015

2015-09-14T21:46:05Z

Mark at 17:48, 27 July 2015

2015-07-27T17:48:01Z

Mark: /* References */

2015-07-11T23:09:55Z

‎References

Mark: /* Functions */

2015-07-11T23:09:37Z

‎Functions

Mark: /* References */

2015-07-01T21:30:03Z

‎References

Mark: /* Functions */

2015-07-01T21:29:23Z

‎Functions

Mark: /* Functions */

2015-04-25T20:39:52Z

‎Functions

Mark at 20:39, 25 April 2015

2015-04-25T20:39:13Z

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP1C]] (catalytic subunit of PP1 holoenzyme)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP1C]] (catalytic subunit of PP1 holoenzyme)
 PPP1C is a ubiquitous serine/threonine phosphatase found throughout eukaryotes and even in some prokaryotes. By forming complexes with different regulatory subunits, it is involved in many various processes.

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 PPP1C, in complex with regulatory subunits, dephosphorylates the substrates below:
-* Myosin (light chain). PPP1C forms [http://en.wikipedia.org/wiki/(myosin-light-chain)_phosphatase myosin-light-chain phosphatase (MLCP)] in complex with [http://en.wikipedia.org/wiki/PPP1R12A PPP1R12A (MYPT1/M130)] and [http://en.wikipedia.org/wiki/PPP1R12B PPP1R12A (M20)].
+* Myosin (light chain). PPP1C forms [http://en.wikipedia.org/wiki/(myosin-light-chain)_phosphatase myosin-light-chain phosphatase (MLCP)] in complex with [http://en.wikipedia.org/wiki/PPP1R12A PPP1R12A (MYPT1/M130)] and [http://en.wikipedia.org/wiki/PPP1R12B PPP1R12B (M20)].
 * eIF2α. PPP1C-PPP1R15A (GADD34) holophosphatase in complex with G-actin, dephosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) and inhibits integrated stress response (ISR) <cite>Chambers15, Rojas15, Choy15</cite>.

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP1C|Subfamily PPP1C]] (PP1)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP1C]] (catalytic subunit of PP1 holoenzyme)
 PPP1C is a ubiquitous serine/threonine phosphatase found throughout eukaryotes and even in some prokaryotes. By forming complexes with different regulatory subunits, it is involved in many various processes.
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 === Functions ===
-The PPP1C subfamily is the catalytic subunit of PP1 holoenzyme binding to regulatory subunits to achieve diverse functions <cite>heroes13</cite>.  Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes, such as cell cycle progression <cite>grallert14</cite> and glycogen metabolism. Below are some examples:
+The PPP1C subfamily is the catalytic subunit of PP1 holoenzyme binding to regulatory subunits to achieve diverse functions <cite>heroes13, Rebelo15</cite>.  Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes, such as cell cycle progression <cite>grallert14</cite> and glycogen metabolism. Below are some examples:
 PPP1C, in complex with regulatory subunits, dephosphorylates the substrates below:
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 * eIF2α. PPP1C-PPP1R15A (GADD34) holophosphatase in complex with G-actin, dephosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) and inhibits integrated stress response (ISR) <cite>Chambers15, Rojas15, Choy15</cite>.
-PPP1C, in complex with its regulatory subunit NIPP1, activates mesenchymal genes in HeLa cells, though its substrates in this biological process are unclear <cite>Dessel15</cite>.
+* NIPP1. PPP1C, in complex with its regulatory subunit NIPP1, activates mesenchymal genes in HeLa cells, though its substrates in this biological process are unclear <cite>Dessel15</cite>.
 ==== Regulatory subunits ====
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 #grallert14 pmid=25487150
 #heroes13 pmid=22360570
 #Rojas15 pmid=26100893
 </biblio>

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP1C|Subfamily PPP1C]] (PP1)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP1C|Subfamily PPP1C]] (PP1)
 PPP1C is a ubiquitous serine/threonine phosphatase found throughout eukaryotes and even in some prokaryotes. By forming complexes with different regulatory subunits, it is involved in many various processes.

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 === References ===
 <biblio>
 #Chambers15 pmid=25774599
 #Choy15 pmid=26095357

← Older revision		Revision as of 23:09, 11 July 2015
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	PPP1C, in complex with its regulatory subunit NIPP1, activates mesenchymal genes in HeLa cells, though its substrates in this biological process are unclear <cite>Dessel15</cite>.		PPP1C, in complex with its regulatory subunit NIPP1, activates mesenchymal genes in HeLa cells, though its substrates in this biological process are unclear <cite>Dessel15</cite>.
		+
		+	==== Regulatory subunits ====
		+	===== PPP1R15B =====
		+	A missense mutation in PPP1R15B causes a syndrome including diabetes, short stature and microcephaly <cite>Abdulkarim15</cite>.

	=== References ===		=== References ===