Phosphatase Subfamily PPP3C - Revision history

Gerard at 17:26, 13 March 2017

2017-03-13T17:26:41Z

Mark: /* PPP3CC */

2017-01-03T17:39:54Z

‎PPP3CC

Mark: /* Functions */

2017-01-03T17:38:08Z

‎Functions

Mark: /* References */

2015-07-06T01:23:42Z

‎References

Mark: /* Functions */

2015-07-06T01:23:23Z

‎Functions

Mark: /* References */

2015-07-05T20:15:35Z

‎References

Mark: /* Functions */

2015-07-05T20:15:16Z

‎Functions

Mark: /* References */

2015-06-02T16:04:48Z

‎References

Mark: /* Functions */

2015-06-02T16:04:24Z

‎Functions

Mark at 17:01, 24 April 2015

2015-04-24T17:01:36Z

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP3C|Subfamily PPP3C]] (PP2B, calcineurin)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP3C|Subfamily PPP3C]] (PP2B, calcineurin)
 PPP3C, the catalytic subunit of PP2B (calcineurin) holoeynzme, is a calcium-dependent serine/threonine phosphatase conserved in eukaryotes. It is involved in various biological processes and has significantly clinic relevance.

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 ==== PPP3CC ====
-PPP3CC is a component of a constitutive intrinsic inflammatory signaling circuit composed of miR-196b, Meis2, PPP3CC, and p65. The signaling circuit drives prostate cancer castration resistance <cite>Jeong2016</cite>.
+PPP3CC is a component of a constitutive intrinsic inflammatory signaling circuit composed of miR-196b, Meis2, PPP3CC, and p65. The signaling circuit drives prostate cancer castration resistance <cite>Jeong2016</cite> (Entitled A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance).
 === References ===

← Older revision		Revision as of 17:38, 3 January 2017
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	Besides, PPP3C (PP2B, calcineurin) is an attractive antifungal drug target <cite> Matsoukas15</cite>, and its inhibitor (FK506 or cyclosporin A) can be combined with azoles or echinocandins for use against multidrug-resistant Candida species <cite>Yu15</cite>.		Besides, PPP3C (PP2B, calcineurin) is an attractive antifungal drug target <cite> Matsoukas15</cite>, and its inhibitor (FK506 or cyclosporin A) can be combined with azoles or echinocandins for use against multidrug-resistant Candida species <cite>Yu15</cite>.
		+
		+	==== PPP3CC ====
		+
		+	PPP3CC is a component of a constitutive intrinsic inflammatory signaling circuit composed of miR-196b, Meis2, PPP3CC, and p65. The signaling circuit drives prostate cancer castration resistance <cite>Jeong2016</cite>.

	=== References ===		=== References ===

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 <biblio>
 #Brignell15 pmid=25793374
 #Matsoukas15 pmid=26106221
 #Orie09 pmid=19422382

← Older revision		Revision as of 01:23, 6 July 2015
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	* PPP3C interacts with Nuclear factor (NF)-κB-inducing kinase (NIK) and attenuates NIK-dependent gene expression <cite>Shinzawa15</cite>.		* PPP3C interacts with Nuclear factor (NF)-κB-inducing kinase (NIK) and attenuates NIK-dependent gene expression <cite>Shinzawa15</cite>.
		+
		+	* In fission yeast, calcineurin interacts with and dephosphorylates kinase Cki3, belonging to CK1-G subfamily, CK1 family, CK1 group. Cki3 autophosphorylate itself in the C terminus, which result in the inhibition of its kinase activity <cite> Koyano15</cite>.

	This phosphatase has clinical significance for schizophrenia and diabetes (see [http://en.wikipedia.org/wiki/Calcineurin wikipedia]).		This phosphatase has clinical significance for schizophrenia and diabetes (see [http://en.wikipedia.org/wiki/Calcineurin wikipedia]).

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 This phosphatase has clinical significance for schizophrenia and diabetes (see [http://en.wikipedia.org/wiki/Calcineurin wikipedia]).
-Besides, PPP3C (PP2B, calcineurin) is an attractive antifungal drug target, and its inhibitor (FK506 or cyclosporin A) can be combined with azoles or echinocandins for use against multidrug-resistant Candida species <cite>Yu15</cite>.
+Besides, PPP3C (PP2B, calcineurin) is an attractive antifungal drug target <cite> Matsoukas15</cite>, and its inhibitor (FK506 or cyclosporin A) can be combined with azoles or echinocandins for use against multidrug-resistant Candida species <cite>Yu15</cite>.
 === References ===

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 #Orie09 pmid=19422382
 #Rusnak00 pmid=11015619
 #Wang15 pmid=25452304
 #Wu14 pmid=24835995
 #Yu15 pmid=25878052
 </biblio>

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 === Functions ===
-PPP3C is the catalytic subunit of Protein Phosphatase 2B (PP2B) holoenzyme (aka calcineurin).  The holoenzyme is heterodimer complex consisting of one catalytic subunit and one regulatory subunit participates in very various cellular processes, from cell cycle progression to cardiac hypertrophy <cite>Rusnak00</cite>.
+PPP3C is the catalytic subunit of Protein Phosphatase 2B (PP2B) holoenzyme (aka calcineurin).  The holoenzyme is heterodimer complex consisting of one catalytic subunit and one regulatory subunit participates in very various cellular processes, from cell cycle progression to cardiac hypertrophy <cite>Rusnak00</cite>. Below are some examples of its function:
-PP2B (calcineurin) activates the T cells of the immune system in mammals. When an antigen-preseting cell interacts with a T cell receptor on T cells, the cytoplasmic level of calcium increases, which activates calcineurin. PP2B (calcineurin) is used as a target for several immunosuppressive drugs, e.g. [http://en.wikipedia.org/wiki/Tacrolimus tacrolimus] which is an immunosuppressive drug used mainly after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection <cite>Wang15</cite>.
+* PP2B (calcineurin) activates the T cells of the immune system in mammals. When an antigen-preseting cell interacts with a T cell receptor on T cells, the cytoplasmic level of calcium increases, which activates calcineurin. PP2B (calcineurin) is used as a target for several immunosuppressive drugs, e.g. [http://en.wikipedia.org/wiki/Tacrolimus tacrolimus] which is an immunosuppressive drug used mainly after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection <cite>Wang15</cite>.
-PP2B (calcineurin) is  included as a key player in mediating calcium-triggered and -accelerated vesicle endocytosis <cite>Wu14</cite>.
+* PP2B (calcineurin) is  included as a key player in mediating calcium-triggered and -accelerated vesicle endocytosis <cite>Wu14</cite>.
-PP2B (Calcineurin) activates a vertebrate-specific transcription factor called NFATc.
+* PP2B (calcineurin) activates a vertebrate-specific transcription factor called NFATc.
-This phosphatase has clinical significance for schizophrenia and diabetes (see [http://en.wikipedia.org/wiki/Calcineurin wikipedia]).
+* PPP3C (PP2B, calcineurin) modulates potassium channel, perhaps by directly controlling the phosphorylation state of potassium channel in collaboration with PKA <cite>Orie09, Brignell15</cite>.
-PPP3C (PP2B, calcineurin) modulates potassium channel, perhaps by directly controlling the phosphorylation state of potassium channel in collaboration with PKA <cite>Orie09, Brignell15</cite>.
+* PPP3C interacts with Nuclear factor (NF)-κB-inducing kinase (NIK) and attenuates NIK-dependent gene expression <cite>Shinzawa15</cite>.
 Besides, PPP3C (PP2B, calcineurin) is an attractive antifungal drug target, and its inhibitor (FK506 or cyclosporin A) can be combined with azoles or echinocandins for use against multidrug-resistant Candida species <cite>Yu15</cite>.