Phosphatase Subfamily PPP4C - Revision history

Gerard at 17:32, 13 March 2017

2017-03-13T17:32:56Z

2015-09-14T16:37:18Z

2015-09-14T16:33:40Z

2015-05-29T04:35:01Z

2015-05-29T04:34:47Z

‎Evolution

2015-05-29T04:32:11Z

‎Evolution

2015-05-29T04:31:41Z

‎Evolution

2015-05-29T04:17:21Z

‎Functions

2015-05-29T04:17:03Z

‎References

2015-05-29T04:16:42Z

‎Functions

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme)
 === Evolution ===

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 Mammal PP4 participates in a number of processes essential for normal cellular physiology, including microtubule organization, homologous recombination (HR)-mediated DNA repair, the DNA damage response, histone modification, apoptosis,  immunoglobulin (Ig) VDJ recombination, pre-TCR signaling, TNF signaling, Toll-like receptor (TLR)-4 signaling, and NF-κB regulation. Germline deletion of PP4 in mice is embryonic lethal, and conditional deletion of PP4 specifically in murine T cells severely impairs T cell development (see introduction in <cite>chen14</cite>).
-PPP4C is implicated in cancer. For instance, high expression of PPP4C is associated with the aggressive malignant behavior of colorectal carcinoma <cite>Li15</cite>.
+See [[Phosphatase_Subfamily_PPP4C_Functions|here]] for unorganized notes of functions.
-−
-PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX.
-−
-PP4 in ''C. elegans'' is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene <cite>sato-carlton14</cite>.
 === References ===
 <biblio>
 #chen14 pmid=25215539
 </biblio>

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme)
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme)
 === Evolution ===

← Older revision		Revision as of 04:35, 29 May 2015
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP\|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP\|Superfamily MTDP]]: [[Phosphatase_Family_PPP\|Family PPP]]: [[Phosphatase_Subfamily_PPP4C\|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme)		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP\|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP\|Superfamily MTDP]]: [[Phosphatase_Family_PPP\|Family PPP]]: [[Phosphatase_Subfamily_PPP4C\|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme)

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 === Evolution ===
-PPP4C is found in [[Phosphatase_Glossary#Opisthokonta|opisthokonta]], amoebazoa and plants. Each of Drosophila melanogaster, C. elegant and monosiga has two PPP4Cs, which arose through different evolutionary events. The second copy of Drosophila melanogaster CG11597 emerged in melanogaster group (see [http://resdev.gene.com/gOrtholog/view/cluster/MC0096611/overview gOrtholog] and [http://arthropods.eugenes.org/DroSpeGe/about/Drosophila-phylogeny.gif Drosophila phylogeny]).
+PPP4C is found in [[Phosphatase_Glossary#Opisthokonta|opisthokonta]], amoebazoa and plants. Each of Drosophila melanogaster, C. elegans and monosiga has two PPP4Cs, which arose through different evolutionary events within individual lineages. For example, the second copy of Drosophila melanogaster CG11597 emerged in melanogaster group (see [http://resdev.gene.com/gOrtholog/view/cluster/MC0096611/overview gOrtholog] and [http://arthropods.eugenes.org/DroSpeGe/about/Drosophila-phylogeny.gif Drosophila phylogeny]).
 === Domain ===

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 #chen14 pmid=25215539
 #Li15 pmid=25927939
-#sato14 pmid=25340746
+#sato-carlton14 pmid=25340746
 </biblio>