Phosphatase Subfamily PPP6C - Revision history

Gerard at 17:26, 13 March 2017

2017-03-13T17:26:21Z

Mark at 17:48, 9 April 2015

2015-04-09T17:48:17Z

Mark: Created page with "Phosphatase Classification: Fold MTDP: Superfamily MTDP: Phosphatase_Family_PPP|Fam..."

2015-01-05T18:31:28Z

Created page with "Phosphatase Classification: Fold MTDP: Superfamily MTDP: Phosphatase_Family_PPP|Fam..."

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP6C|Subfamily PPP6C]]

=== Evolution ===
PPP6C is found throughout eukaryotes, including [[Phosphatase_Glossary#Opisthokonta|opisthokonta]], amoebazoa, plants and etc.

=== Domain ===
PPP6C has a single domain - phosphatase domain.

=== Functions ===
PPP6C, catalytic subunit of Protein Phosphatase 6 (PP6) holoenzyme.

The PP6 holoenzyme in yeast has been proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS (SIT4 phosphatase-associated proteins) domain-containing sub- unit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL-2 receptor stimulation. Its N-terminal domain restricts G to S phase progression in cancer cells, in part through control of cyclin D1. PP6 is akso required for efficient activation of DNA-PK,21 which is essential for NHEJ-mediated repair of DSBs (reviewed in the introduction of <cite>zhong11</cite>).

=== References ===
<biblio>
#zhong11 pmid=21451261
</biblio>

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP6C|Subfamily PPP6C]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]:  [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP6C|Subfamily PPP6C]]
 === Evolution ===

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP6C|Subfamily PPP6C]]
@@ Line 10: / Line 11: @@
 PPP6C, catalytic subunit of Protein Phosphatase 6 (PP6) holoenzyme.
-The PP6 holoenzyme in yeast has been proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS (SIT4 phosphatase-associated proteins) domain-containing sub- unit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL-2 receptor stimulation. Its N-terminal domain restricts G to S phase progression in cancer cells, in part through control of cyclin D1. PP6 is akso required for efficient activation of DNA-PK,21 which is essential for NHEJ-mediated repair of DSBs (reviewed in the introduction of <cite>zhong11</cite>).
+The PP6 holoenzyme in yeast has been proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS (SIT4 phosphatase-associated proteins) domain-containing sub- unit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
 === References ===
 <biblio>
 #zhong11 pmid=21451261
 </biblio>