Phosphatase Subfamily PTPMT1 - Revision history

Mark at 05:12, 27 February 2015

2015-02-27T05:12:42Z

Mark at 05:12, 27 February 2015

2015-02-27T05:12:26Z

Mark at 05:11, 27 February 2015

2015-02-27T05:11:54Z

Gerard at 01:27, 28 December 2014

2014-12-28T01:27:54Z

Gerard at 01:25, 28 December 2014

2014-12-28T01:25:26Z

Gerard: Created page with "Phosphatase Classification: Superfamily CC1: Family DSP and PTEN: PTPMT1|Sub..."

2014-12-28T01:25:01Z

Created page with "Phosphatase Classification: Superfamily CC1: Family DSP and PTEN: PTPMT1|Sub..."

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1I|Superfamily CC1]]: [[Phosphatase_Family_DSP_PTEN|Family DSP and PTEN]]: [[PTPMT1|Subfamily PTPMT1]]

PTPMT1 (or PLIP) is the first member of PTP superfamily found exclusively localized to the mitochondrion <cite>pmid16039589</cite>. It was originally discovered as an open reading frame encoding a phosphatase with sequence similarity to the tumor suppressor PTEN <cite>pmid15247229</cite>. Like PTEN, PTPMT1 possesses very poor activity toward proteinaceous substrates <cite>pmid15247229</cite>. In vitro, it specifically dephosphorylates phosphatidylinositol 5-phosphate (PI5P), displaying much less activity against any other phosphoinositides <cite>pmid15247229</cite>. However, depletion of PTPMT1 in cells produces no effect on the cellular level of PI5P, suggesting that PI5P is not the endogenous substrate <cite>pmid16039589</cite>. Later, it has been found that PTPMT1 is a mitochondrial phosphatase that converts phosphatidylglycerolphosphate (PGP) to phosphatidylglycerol, a critical step in the de novo biosynthesis of cardiolipin <cite>zhang11</cite>. It is found in most or all animals and higher plants, but is absent from fungi, Monosiga, and lower plants. It is also found in several protists, including ''Dictyostelium'' , ''Leishamania'', ''Trypanosomes'', ''Ectocarpus'', and diatoms. More surprisingly, a functional PTPMT1 is found in a eubacterium Rhodopirellula baltica <cite>Teh13</cite>.

Acknowledgement. Thank Ji Zhang at UC San Diego for her contribution.

== References ==

<biblio>
#zhang11 pmid=21641550
#Teh13 pmid=23293031
#pmid15247229 pmid=15247229
#pmid16039589 pmid=16039589
</biblio>

← Older revision		Revision as of 05:12, 27 February 2015
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_DSP\|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_DSP\|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]

← Older revision		Revision as of 05:12, 27 February 2015
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[~~Phosphatase_Superfamily_CC1I~~\|Superfamily CC1]]: [[Phosphatase_Family_DSP\|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_DSP\|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]

	=== Evolution ===		=== Evolution ===

← Older revision		Revision as of 01:27, 28 December 2014
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1I\|Superfamily CC1]]: [[~~Phosphatase_Family_DSP_PTEN~~\|Family DSP ~~and PTEN~~]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1I\|Superfamily CC1]]: [[Phosphatase_Family_DSP\|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]

← Older revision		Revision as of 01:25, 28 December 2014
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1I\|Superfamily CC1]]: [[Phosphatase_Family_DSP_PTEN\|Family DSP and PTEN]]: [[~~PTPMT1~~\|Subfamily PTPMT1]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1I\|Superfamily CC1]]: [[Phosphatase_Family_DSP_PTEN\|Family DSP and PTEN]]: [[Phosphatase_Subfamily_PTPMT1\|Subfamily PTPMT1]]

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Superfamily_CC1I|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_PTPMT1|Subfamily  PTPMT1]]
-PTPMT1 (or PLIP)  is the first member of PTP superfamily found exclusively localized to the mitochondrion <cite>pmid16039589</cite>. It was originally discovered as an open reading frame encoding a phosphatase with sequence similarity to the tumor suppressor PTEN <cite>pmid15247229</cite>. Like PTEN, PTPMT1 possesses very poor activity toward proteinaceous substrates <cite>pmid15247229</cite>. In vitro, it specifically dephosphorylates phosphatidylinositol 5-phosphate (PI5P), displaying much less activity against any other phosphoinositides <cite>pmid15247229</cite>. However, depletion of PTPMT1 in cells produces no effect on the cellular level of PI5P, suggesting that PI5P is not the endogenous substrate <cite>pmid16039589</cite>. Later, it has been found that PTPMT1 is a mitochondrial phosphatase that converts phosphatidylglycerolphosphate (PGP) to phosphatidylglycerol, a critical step in the de novo biosynthesis of cardiolipin <cite>zhang11</cite>. It is found in most or all animals and higher plants, but is absent from fungi, Monosiga, and lower plants. It is also found in several protists, including ''Dictyostelium'' , ''Leishamania'', ''Trypanosomes'', ''Ectocarpus'', and diatoms. More surprisingly, a functional PTPMT1 is found in a eubacterium Rhodopirellula baltica <cite>Teh13</cite>.
+=== Domain ===
-Acknowledgement. Thank Ji Zhang at UC San Diego for her contribution.
+=== Function ===
-== References ==
+=== Acknowledgement ===
 <biblio>
 #zhang11 pmid=21641550