Phosphatase Subfamily PTPN1 - Revision history

Mark at 16:06, 22 June 2015

2015-06-22T16:06:37Z

Mark at 15:59, 22 June 2015

2015-06-22T15:59:21Z

Mark: /* References */

2015-06-15T18:35:26Z

‎References

Mark: /* Misc. */

2015-06-15T18:35:05Z

‎Misc.

Mark: /* References */

2015-06-01T17:46:53Z

‎References

Mark: /* Functions */

2015-06-01T17:46:39Z

‎Functions

Mark: /* References */

2015-04-22T17:31:44Z

‎References

Mark: /* Functions */

2015-04-22T17:31:32Z

‎Functions

Mark at 23:49, 24 March 2015

2015-03-24T23:49:17Z

Mark at 21:09, 17 December 2014

2014-12-17T21:09:46Z

@@ Line 19: / Line 19: @@
 * Human PTPN1 (PTPB1) is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>.
 * Human PTPN1 (PTPB1) plays a key role in regulating dendritic cell maturation, migration and T cell activation <cite>Martin-Granados15</cite>.
 ===== Human PTPN2 =====
@@ Line 31: / Line 32: @@
 #Martin-Granados15 pmid=26063615
 #Ren15 pmid=26026268
 #Tiganis13 pmid=22404968
 #Tonks03 pmid=12829250

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]]
@@ Line 14: / Line 12: @@
 The PTPN1 subfamily has various functions <cite>Zabolotny02, Tonks03, Zhang07, Tiganis13</cite>. It dephoshorylates kinases of various families, such as Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2):
 * BRK. PTPN1 (PTP1B) inhibited BRK, a member of SRM subfamily, SRC family, by directly dephosphorylating the Tyr-342 autophosphorylation site <cite>Fan15</cite>.
-* STAT3. PTPN2 (TCPTP) interacts with, dephosphorylates and inactivates STAT3. The activity is enhanced by STAT3-Interacting Protein As a Repressor (SIPAR) <cite>Ren15</cite>.
+====== Other functions and regulatory mechanisms ======
-−
-===== Miscellaneous functions and regulatory mechanisms =====
 * Human PTPN1 (PTPB1) is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>.
 * Human PTPN1 (PTPB1) plays a key role in regulating dendritic cell maturation, migration and T cell activation <cite>Martin-Granados15</cite>.
 ===References===

@@ Line 26: / Line 26: @@
 #Barrett99 pmid=10350489
 #Fan15 pmid=25897081
 #Ren15 pmid=26026268
 #Tiganis13 pmid=22404968

@@ Line 18: / Line 18: @@
 * STAT3. PTPN2 (TCPTP) interacts with, dephosphorylates and inactivates STAT3. The activity is enhanced by STAT3-Interacting Protein As a Repressor (SIPAR) <cite>Ren15</cite>.
-===== Misc. =====
+===== Miscellaneous functions and regulatory mechanisms =====
-PTPN1 is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>.
+* Human PTPN1 (PTPB1) is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>.
 ===References===

@@ Line 25: / Line 25: @@
 #Barrett99 pmid=10350489
 #Fan15 pmid=25897081
 #Tiganis13 pmid=22404968
 #Tonks03 pmid=12829250

@@ Line 12: / Line 12: @@
 ===Functions===
-The PTPN1 subfamily has various functions <cite>Zabolotny02, Tonks03, Zhang07, Tiganis13</cite>. It dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2).
+The PTPN1 subfamily has various functions <cite>Zabolotny02, Tonks03, Zhang07, Tiganis13</cite>. It dephoshorylates kinases of various families, such as Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2).
 PTPN1 is regulated via glutathionylation of cysteine at the catalytic motif Cx5R <cite>Barrett99</cite>.

@@ Line 1: / Line 1: @@
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]]
+__NOTOC__
-PTPN1 subfamily dephoshorylate kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). The phosphatase emerged later than the related kinases. The phosphatase first emerged in Trichoplax. EGFR is conserved from sponge to human but lost in Trichoplax, and InsR is conserved from Trichoplax to human.
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]]
-=== Evolution ===
+The PTPN1 subfamily dephoshorylates kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2).
-PTPN1 subfamily emerged in animals, as it is found in most if not all eumetazoa, Porifera (e.g. sponge) and Placozoa (e.g. Trichoplax), but absent from Choanoflagellata (e.g. Monosiga) (for the phylogeny of animal at [http://en.wikipedia.org/wiki/Animal#Ctenophora.2C_Porifera.2C_Placozoa.2C_Cnidaria_and_Bilateria here]). In human, there are two copies:  [[Phosphatase_Gene_PTPN1|PTPN1 (PTP1B)]] and [[Phosphatase_Gene_PTPN2|PTPN2]]. The two copies can be traced back to the time when vertebrates emerged. The orthologs for each of them are found in most vertebrates from fish to primates, and there is a single copy in non-vertebrate metazoa.
-It substrate EGFR is conserved from sponge to human but lost in Trichoplax, and InsR is conserved from Trichoplax to human.
+===Evolution===
-(PS: Why PTPN1 and PTPN2 have different functions?)
+===Domain ===