Phosphatase Subfamily PTPN9 - Revision history

Gerard at 17:54, 16 March 2017

2017-03-16T17:54:29Z

Mark: /* References */

2015-03-18T00:17:54Z

‎References

Mark: /* Functions */

2015-03-18T00:17:38Z

‎Functions

Mark at 00:16, 18 March 2015

2015-03-18T00:16:09Z

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1:Superfamily CC1: Phosphatase_Family_P..."

2015-03-17T16:11:31Z

Created page with "__NOTOC__ Phosphatase Classification: Fold CC1:Superfamily CC1: Phosphatase_Family_P..."

New page

__NOTOC__

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN9|Subfamily PTPN9]] (MEG2/PTPMEG2)

===Evolution===

===Domain ===
PTPN9 has two domains: a N-terminal domain homologous to yeast SEC14p and a C-terminal phosphatase domain <cite>Gu92</cite>.

===Functions===
PTPN9 is widely expressed in different tissues <cite>Gu92</cite> (also see [http://www.gtexportal.org/home/gene/PTPN9 GTEx]).

===References===
<biblio>
#Gu92 pmid=1557404
</biblio>

@@ Line 3: / Line 3: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN9|Subfamily PTPN9]] (MEG2/PTPMEG2)
-PTPN9/MEG2 is a metazoan subfamily functions in regulated secretory pathway. It has a characteristic accessory domain, a N-terminal Sec14p homology domain, which localizes it to secretory vesicles.
+PTPN9 (MEG2) is a non-receptor tyrosine phosphatase involved in vesicle fusion in the secretory pathway.
 ===Evolution===
-PTPN9 emerged in metazoan, usually one copy per genome.
+PTPN9 emerged is found in animals, usually as a single copy. It is absent from nematodes
 ===Domain ===
@@ Line 16: / Line 16: @@
 PTPN9 is widely expressed in different tissues <cite>Gu92</cite> (also see [http://www.gtexportal.org/home/gene/PTPN9 GTEx]).
-PTPN9/PTPMEG2 plays important role in regulated secretory pathway. It induces homotypic secretory vesicle fusion in cells. PTPN9/PTPMEG2 localizes to secretory vesicle membranes through its N-terminal Sec14p homolog domain binding to phosphatidylinositol-3,4,5-trisphosphate <cite>Huynh03</cite> and/or mannose 6-phosphate receptor-interacting protein TIP47 and Arfaptin2 on vesicles <cite>Saito07</cite>. It dephosphorylates N-ethylmaleimide-sensitive factor (NSF), a key regulator of vesicle fusion, at Tyr 83, which resulted in the local release of NSF from a tyrosine-phosphorylated, inactive state <cite>Huynh04</cite>.
+PTPN9 plays important role in regulated secretion. It localizes to secretory vesicle membranes through its N-terminal Sec14p homolog domain binding to phosphatidylinositol-3,4,5-trisphosphate <cite>Huynh03</cite> and/or mannose 6-phosphate receptor-interacting protein TIP47 and Arfaptin2 on vesicles <cite>Saito07</cite>. It induces homotypic secretory vesicle fusion. It dephosphorylates N-ethylmaleimide-sensitive factor (NSF), a key regulator of vesicle fusion, at Tyr 83, which resulted in the local release of NSF from a tyrosine-phosphorylated, inactive state <cite>Huynh04</cite>.
-PTPN9/PTPMEG2 localizes to secondary and tertiary granules and secretory vesicles in neutrophils, and may regulate phagocytosis, an essential antimicrobial function in the innate immune response <cite>Kruger02</cite>.
+PTPN9 localizes to secondary and tertiary granules and secretory vesicles in neutrophils, and may regulate phagocytosis, an essential antimicrobial function in the innate immune response <cite>Kruger02</cite>, and is involved in the development of erythroid cells <cite>Xu03</cite>.
-PTPN9/PTPMEG2 directly interacts with STAT3 and mediates its dephosphorylation in the cytoplasm <cite>Su12</cite>.
+PTPN9 directly interacts with STAT3 and mediates its dephosphorylation in the cytoplasm <cite>Su12</cite>.
-PTPN9/PTPMEG2 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells <cite>Yuan10</cite>, and vascular endothelial growth factor receptor (perhaps on Tyr-1175) in endothelial cells <cite>Hao12</cite>.
+PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells <cite>Yuan10</cite>, and vascular endothelial growth factor receptor (perhaps on Tyr-1175) in endothelial cells <cite>Hao12</cite>.
-−
-PTPN9/PTPMEG2 has an important role in the development of erythroid cells <cite>Xu03</cite>.
 The human gene is implicated in signaling between insulin receptor (InsR) and the FoxO transcription factor <cite>Cho06</cite>.

@@ Line 24: / Line 24: @@
 PTPN9/PTPMEG2 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells <cite>Yuan10</cite>, and vascular endothelial growth factor receptor (perhaps on Tyr-1175) in endothelial cells <cite>Hao12</cite>.
-PTPN9/PTPMEG2 also has an important role in the development of erythroid cells <cite>Xu03</cite>.
+PTPN9/PTPMEG2 has an important role in the development of erythroid cells <cite>Xu03</cite>.
 ===References===