Phosphatase Subfamily PTPRG - Revision history

Gerard: /* Functions */

2017-04-02T05:52:36Z

‎Functions

2017-04-02T05:51:53Z

‎Evolution

2017-04-02T05:51:43Z

‎Evolution

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‎Domain

2016-03-22T18:28:48Z

‎Evolution

2015-10-14T18:02:56Z

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2015-09-14T16:59:47Z

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‎Functions

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 The vertebrate forms are expressed in brain and involved in cell adhesion. Drosophila ptp99a is also selectively expressed and functions in the nervous system, interacting with other RPTPs, including Dlar and ptp69D.
-PTPRG is suggested to be a tumor suppressor due to it's frequent loss or decreased expression in a number of cancer types.
+PTPRG is suggested to be a tumor suppressor due to its frequent loss or decreased expression in a number of cancer types.
 The phosphatase activity is modulated by the ligands binding to extracellular region <cite>Mohebiany13</cite> and other proteins binding to the cytoplasmic region <cite>Shen15</cite>.

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 ===Evolution===
- PTPRG is bilaterian, typically single-copy, but expanded to two genes, PTPRG and PTPRZ1 (Rptpζ) in human and other vertebrates.
+PTPRG is bilaterian, typically single-copy, but expanded to two genes, PTPRG and PTPRZ1 (Rptpζ) in human and other vertebrates.
 ===Domain ===

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 ===Evolution===
-The PTPRG subfamily is found in bilaterian, typically single-copy, but expanded to two genes, PTPRG and PTPRZ1 (Rptpζ) in human and other vertebrates.
+ PTPRG is bilaterian, typically single-copy, but expanded to two genes, PTPRG and PTPRZ1 (Rptpζ) in human and other vertebrates.
 ===Domain ===

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 __NOTOC__
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRG|Subfamily PTPRG]]
-PTPRG is a receptor PTP subfamily involved in eumetazoan neural development and maybe cancer.
+PTPRG is a receptor PTP involved in neural development and maybe cancer.
 ===Evolution===

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 ===Domain ===
-These are receptor PTPs with dual intracellular catalytic domains. The extracellular domain contains at least one FN3 domain. Vertebrate members have a catalytically inactive carbonic anhydrase (CA) domain (see [[Phosphatase_Subfamily_PTPRG_Tech_Note|technical notes]]), while most invertebrates, including one invertebrate chordate, have additional Ig and FN3 repeats instead. The CA domain acts as a receptor for members of the contactin family of neural cell adhesion molecules <cite>Bouyain</cite>.
+These are receptor PTPs with dual intracellular catalytic domains. The extracellular domain contains at least one FN3 domain. Vertebrate members have a catalytically inactive carbonic anhydrase (CA) domain (see [[Phosphatase_Subfamily_PTPRG_Tech_Note|technical notes]]), while most invertebrates, including one invertebrate chordate, have additional Ig and FN3 repeats instead. The CA domain acts as a receptor for members of the contactin family of neural cell adhesion molecules <cite>Bouyain</cite>. Most mammalian PTPRGs lack a predicted signal peptide, though they align weakly with the signal peptide of PTPRZ1; fish and some other non-mammalian PTPRG have strong predicted signal peptides.
 ===Functions===

← Older revision		Revision as of 17:42, 14 October 2015
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	[[Phosphatase_Subfamily_PTPRG_Functions\|Here]] are the unorganized notes on functions.		[[Phosphatase_Subfamily_PTPRG_Functions\|Here]] are the unorganized notes on functions.
		+
		+	=== [[Phosphatase_Subfamily_PTPRG_Tech_Note\|Technical notes]] ===

	===References===		===References===

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 ===Evolution===
-The PTPRG subfamily is found in eumetazoans, typically single-copy, but expanded to two genes, PTPRG and PTPRZ in human and other vertebrates.
+The PTPRG subfamily is found in eumetazoans, typically single-copy, but expanded to two genes, PTPRG and PTPRZ1 (Rptpζ) in human and other vertebrates.
 ===Domain ===

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 PTPRG has various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques, and a natural soluble protein in plasma has been identified by experimental assays <cite>Moratti15</cite>.
 PTPRZ1-MET (ZM) fusion protein is identified in human gliomas by high-throughput transcriptome sequencing, which induces gliomas through elevated expression and phosphorylation of the MET oncoprotein <cite>Chen15</cite>.
 ===References===