Phosphatase Subfamily PTPRG Tech Note - Revision history

Mark: /* The gain of N-terminal Carbonic anhydrase (CA) domain */

2015-10-14T18:15:57Z

‎The gain of N-terminal Carbonic anhydrase (CA) domain

2015-10-14T17:58:16Z

2015-10-14T17:43:25Z

2015-10-14T17:43:08Z

Created page with "Phosphatase Classification: Fold CC1:Superfamily CC1: Phosphatase_Family_PTP|Family P..."

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← Older revision		Revision as of 18:15, 14 October 2015
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	=== The gain of N-terminal Carbonic anhydrase (CA) domain ===		=== The gain of N-terminal Carbonic anhydrase (CA) domain ===
−	We BLASTed the N-terminal CA domain sequence determined by CDD (1-275 of human PTPRG) against i) all eukaryotes, ii) animals except vertebrates, iii) deuterostomes except vertebrates and iv) vertebrates~~, in a narrow-down approach~~. In invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrates (lamprey lacks CA domain due to the incomplete gene model). In sum, the CA domain was gained in vertebrates.	+	We found the origin of CA domain in a narrow-down approach by BLASTing the sequence of CA domain against different clades. We BLASTed the N-terminal CA domain sequence determined by CDD (1-275 of human PTPRG) against protein NR datasets, with the phylogeny as i) all eukaryotes, ii) animals except vertebrates, iii) deuterostomes except vertebrates and iv) vertebrates. In invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrates (lamprey lacks CA domain due to the incomplete gene model). In sum, the CA domain was gained in vertebrates.

← Older revision		Revision as of 17:58, 14 October 2015
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	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPRG\|Subfamily PTPRG]]: [[Phosphatase_Subfamily_PTPRG_Tech_Note\|Technical notes]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPRG\|Subfamily PTPRG]]: [[Phosphatase_Subfamily_PTPRG_Tech_Note\|Technical notes]]
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		+	=== The gain of N-terminal Carbonic anhydrase (CA) domain ===
		+	We BLASTed the N-terminal CA domain sequence determined by CDD (1-275 of human PTPRG) against i) all eukaryotes, ii) animals except vertebrates, iii) deuterostomes except vertebrates and iv) vertebrates, in a narrow-down approach. In invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrates (lamprey lacks CA domain due to the incomplete gene model). In sum, the CA domain was gained in vertebrates.

← Older revision		Revision as of 17:43, 14 October 2015
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPRG\|Subfamily PTPRG]]: [[~~Phosphatase_Subfamily_PTPR_Tech_Note~~\|Technical notes]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPRG\|Subfamily PTPRG]]: [[Phosphatase_Subfamily_PTPRG_Tech_Note\|Technical notes]]