Phosphatase Subfamily Ptp69D - Revision history

Mark at 16:41, 29 May 2015

2015-05-29T16:41:53Z

Mark: Mark moved page Subfamily Ptp69D to Phosphatase Subfamily Ptp69D: Standardize URL pattern

2014-12-10T20:43:29Z

Mark moved page Subfamily Ptp69D to Phosphatase Subfamily Ptp69D: Standardize URL pattern

Mark at 07:00, 10 December 2014

2014-12-10T07:00:04Z

Gerard at 05:53, 10 December 2014

2014-12-10T05:53:38Z

Gerard at 05:52, 10 December 2014

2014-12-10T05:52:56Z

Mark: Created page with "Phosphatase Classification: Superfamily CC1: PTP: Ptp69D"

2014-12-09T20:03:01Z

Created page with "Phosphatase Classification: Superfamily CC1: PTP: Ptp69D"

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|PTP]]: [[Subfamily_Ptp69D|Ptp69D]]

← Older revision		Revision as of 16:41, 29 May 2015
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	__NOTOC__		__NOTOC__

−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[~~Subfamily_Ptp69D~~\|Subfamily Ptp69D]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_Ptp69D\|Subfamily Ptp69D]]

← Older revision		Revision as of 07:00, 10 December 2014
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	__NOTOC__		__NOTOC__

−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[~~Phosphatase_Subfamily_Ptp69D~~\|Subfamily Ptp69D]]	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Subfamily_Ptp69D\|Subfamily Ptp69D]]

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 ===Evolution===
 PTP69D is found in bilateral metazoans, but appears to be lost in vertebrates, though the vertebrate PTPRA family is highly similar in phosphatase domain sequence to PTP69D.
 ===Domain Structure===

← Older revision		Revision as of 05:52, 10 December 2014
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|PTP]]: [[~~Subfamily_Ptp69D~~\|Ptp69D]]	+	__NOTOC__
		+
		+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_Ptp69D\|Subfamily Ptp69D]]
		+
		+
		+	PTP69D is a receptor PTP family involved in metazoan neural development.
		+
		+	===Evolution===
		+	PTP69D is found in bilateral metazoans, but appears to be lost in vertebrates, though the vertebrate PTPRA family is highly similar in phosphatase domain sequence to PTP69D.
		+
		+
		+	===Domain Structure===
		+	These have dual intracellular PTP phosphatases domains and extracllular Ig and FN3 repeats.
		+	Phosphatase domains are most similar to PTPRA, a vertebrate-specific family with a shorter extracellular region with an endomucin-like domain.
		+
		+	===Functions===
		+	C. elegans clr-1 is involved in the FGFR signaling pathway, where it suppresses the egl-15 RTK <cite>Kokel</cite> and is involved in netrin-dependent axonal guidance <cite>Chang</cite>. Drosophila Ptp69D is also involved in axonal guidance <cite>Marlo</cite>, in part by antagonizing Abl kinase signaling <cite>Song</cite>.
		+
		+	===References===
		+	<biblio>
		+	#Chang pmid=15232111
		+	#Kokel pmid=9585503
		+	#Marlo pmid=16514605
		+	#Song pmid=18160268
		+	</biblio>

← Older revision	Revision as of 20:43, 10 December 2014
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