Mark: Created page with "NOTOC Phosphatase Classification: Fold RTR1: Superfamily RTR1: Phosphatase_Fami..."

2015-01-01T17:00:15Z

Created page with "__NOTOC__ Phosphatase Classification: Fold RTR1: Superfamily RTR1: Phosphatase_Fami..."

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__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_RTR1|Fold RTR1]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]: [[Phosphatase_Family_RTR1|Family RTR1]]: [[Phosphatase_Subfamily_RTR1|Subfamily RTR1]]

RTR1 is a phosphatase conserved in eukaryotes that regulates the [[CTD_Phosphorylation|phosphorylation states of C-terminal domain (CTD) of RNA polymerase II]].

=== Evolution ===
RTR1 is found in most of eukaryotes. It is absent from Monosiga and sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast.

=== Domain ===
RTR1 has a conserved domain that carries out the phosphatase activity. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. Human RTR1 encoded by gene RPAP2 has a longer tail, but whether its function is unclear given the limited sequence similarity with CTR in yeast RTR1.

=== Function ===
Yeast RTR1 encodes the phosphatase that dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite>. Moreover, it has been shown that Rtr1 dephosphorylates not only serine-5 but also the newly described anti-termination tyrosine 1 marker on CTD repeats <cite>hsu14</cite>.

=== References ===
<biblio>
#Mosley09 pmid=19394294
#Kim09 pmid=19679665
#xiang12 pmid=22781759
#hsu14 pmid=24951832
</biblio>

Phosphatase Subfamily RTR1 - Revision history

Mark: Created page with "__NOTOC__ Phosphatase Classification: Fold RTR1: Superfamily RTR1: Phosphatase_Fami..."

Mark: Created page with "NOTOC Phosphatase Classification: Fold RTR1: Superfamily RTR1: Phosphatase_Fami..."