Phosphatase Subfamily SCP - Revision history

Gerard: /* Evolution */

2017-03-22T01:01:01Z

‎Evolution

Mark at 19:04, 28 May 2015

2015-05-28T19:04:19Z

Mark at 19:03, 28 May 2015

2015-05-28T19:03:13Z

Mark at 17:23, 22 April 2015

2015-04-22T17:23:24Z

Mark at 17:20, 22 April 2015

2015-04-22T17:20:00Z

Mark at 04:00, 1 January 2015

2015-01-01T04:00:43Z

Gerard: Gerard moved page SCP to Phosphatase Subfamily SCP

2014-12-30T06:46:49Z

Gerard moved page SCP to Phosphatase Subfamily SCP

Mark: Created page with "==Phosphatase Classification: FCP:SCP== == Introduction == SCP is named after Small CTD (carboxy-terminal domain..."

2014-03-14T18:10:42Z

Created page with "==Phosphatase Classification: FCP:SCP== == Introduction == SCP is named after Small CTD (carboxy-terminal domain..."

New page

==[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[SCP]]==

== Introduction ==
SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD <cite>Zhang06</cite>.

== Substrates and Related Kinases ==
See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].

== Evolutionary History ==
SCP is conserved from yeast to human.

== Domain Combination ==

== Catalytic activity ==

== Curation notes ==

== References ==

<biblio>
#Zhang06 pmid=17157258
</biblio>

== Links ==
[http://www.ncbi.nlm.nih.gov/gene/58190 Human CTDSP1], [http://www.ncbi.nlm.nih.gov/gene/10106 CTDSP2], and [http://www.ncbi.nlm.nih.gov/gene/10217 CTDSPL] from NCBI Gene

@@ Line 5: / Line 5: @@
 === Evolution ===
-SCP is conserved from yeast to human.  The SCP subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL).
+SCP is conserved from yeast to human.  The SCP subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). CTDSPL2 is a member of a different subfamily.
 === Domain Combination ===

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_SCP|Subfamily SCP]]
+[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_SCP|Subfamily SCP]] (Small CTD Phosphatase)
 SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase.

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_SCP|Subfamily SCP]]
-SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD <cite>Zhang06</cite>. See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].
+SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase.
 === Evolution ===
-SCP is conserved from yeast to human.
+SCP is conserved from yeast to human.  The SCP subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL).
 === Domain Combination ===
@@ Line 11: / Line 11: @@
 === Functions ===
 Human SCP1 prefers to dephosphorylate pSer5 at CTD <cite>Zhang06</cite>. See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]] for other CTD phosphatases.
 SCP1 also dephosphorylates c-Myc at Serine-62 which affects its stability in cancer cells <cite>Wang15</cite>.
 === References ===
 <biblio>
 #Wang15 pmid=25893300
 #Zhang06 pmid=17157258

@@ Line 1: / Line 1: @@
 __NOTOC__
 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_SCP|Subfamily SCP]]
-=== Introduction ===
+=== Evolution ===
-SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD <cite>Zhang06</cite>.
-−
-=== Substrates and Related Kinases ===
-See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].
-−
-=== Evolutionary History ===
 SCP is conserved from yeast to human.
 === Domain Combination ===
-=== Catalytic activity ===
+SCP1 also dephosphorylates c-Myc at Serine-62 which affects its stability in cancer cells <cite>Wang15</cite>.
-−
-−
-== References ==
 <biblio>
 #Zhang06 pmid=17157258
 </biblio>
+=== Links ===
 == Links ==
 [http://www.ncbi.nlm.nih.gov/gene/58190 Human CTDSP1], [http://www.ncbi.nlm.nih.gov/gene/10106 CTDSP2], and [http://www.ncbi.nlm.nih.gov/gene/10217 CTDSPL] from NCBI Gene

← Older revision		Revision as of 17:20, 22 April 2015
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		+	__NOTOC__
		+
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HAD\|Fold HAD]]: [[Phosphatase_Superfamily_HAD\|Superfamily HAD]]: [[Phosphatase_Family_FCP\|Family FCP]]: [[Phosphatase_Subfamily_SCP\|Subfamily SCP]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HAD\|Fold HAD]]: [[Phosphatase_Superfamily_HAD\|Superfamily HAD]]: [[Phosphatase_Family_FCP\|Family FCP]]: [[Phosphatase_Subfamily_SCP\|Subfamily SCP]]

← Older revision	Revision as of 06:46, 30 December 2014
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