Phosphatase Subfamily egg - Revision history

Gerard: /* Domain */

2016-09-07T21:29:38Z

‎Domain

Gerard: /* Evolution */

2016-09-07T21:26:29Z

‎Evolution

Gerard: /* Domain */

2016-09-07T21:26:18Z

‎Domain

Gerard: /* Function */

2016-09-07T21:20:23Z

‎Function

Gerard: /* Function */

2016-09-07T21:12:20Z

‎Function

Mark at 17:27, 29 May 2015

2015-05-29T17:27:41Z

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_P..."

2015-05-29T17:13:30Z

Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_P..."

New page

__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_egg|Subfamily Egg]]

=== Evolution ===
The eak subfamily is nematode specific. ''C. elegans'' has three members: egg-3, egg-4, egg-5.

=== Domain ===
The egg subfamily has a single structural domain: the phosphatase domain of CC1 fold.

=== Function ===

=== References ===
<biblio>

</biblio>

@@ Line 6: / Line 6: @@
 === Domain ===
-The egg subfamily has a single structural domain: a CC1-fold phosphatase domain.
+The egg subfamily has a single structural domain: a CC1-fold phosphatase domain. egg-4/5 have about 200AA of unconserved sequence upstream, while egg-3 has about 200 AA of sequence with no sequence similarity beyond nematode orthologs of these genes.
 === Function ===

@@ Line 9: / Line 9: @@
 === Function ===
-All three ''C. elegans'' members are predicted to be catalytically inactive, due to loss of the cysteine and/or arginine of the Cx5R motif. egg-4 and egg-5 control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>.
+All three ''C. elegans'' members are predicted to be catalytically inactive, due to loss of the cysteine or arginine of the Cx5R motif. The near-identical proteins, egg-4 and egg-5, control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>.
 === References ===

@@ Line 9: / Line 9: @@
 === Function ===
-In ''C. elegans'', all three members are predicted to be catalytically inactive as the replacements at cysteine and/or arginine at Cx5R motif. Egg-4 and egg-5 functions in controlling the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. Egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>.
+All three ''C. elegans'' members are predicted to be catalytically inactive, due to loss of the cysteine and/or arginine of the Cx5R motif. egg-4 and egg-5 control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>.
 === References ===

@@ Line 3: / Line 3: @@
 === Evolution ===
-The eak subfamily is nematode specific. ''C. elegans'' has three members: egg-3, egg-4, egg-5.
+The egg subfamily is nematode specific. ''C. elegans'' has three members: egg-3, egg-4, egg-5.
 === Domain ===

Phosphatase Subfamily egg - Revision history

Gerard: /* Domain */

Gerard: /* Evolution */

Gerard: /* Domain */

Gerard: /* Function */

Gerard: /* Function */

Mark at 17:27, 29 May 2015

Mark: Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_P..."

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_P..."