Phosphatase Superfamily Cys-based III - Revision history

Gerard: Replaced content with "==Deprecated=="

2014-12-06T20:28:21Z

Replaced content with "==Deprecated=="

Gerard at 20:22, 6 December 2014

2014-12-06T20:22:18Z

Mark at 01:11, 16 June 2014

2014-06-16T01:11:19Z

Mark at 19:39, 27 May 2014

2014-05-27T19:39:55Z

Gerard at 23:35, 26 May 2014

2014-05-26T23:35:14Z

Gerard at 23:34, 26 May 2014

2014-05-26T23:34:59Z

Gerard at 01:16, 1 May 2014

2014-05-01T01:16:12Z

Mark at 17:55, 30 April 2014

2014-04-30T17:55:33Z

Mark at 17:55, 30 April 2014

2014-04-30T17:55:16Z

Mark at 17:51, 30 April 2014

2014-04-30T17:51:00Z

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-__NOTOC__
+==Deprecated==
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC2|Superfamily CC2]]
-−
-This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_CC1|superfamily CC1]] and [[Phosphatase_Superfamily_CC2|superfamily CC2]].
-−
-The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Despite having only 15% sequence identity, human LMWPTP and SSU72 structures superimpose with an rmsd of 1.7 Å <cite>zhangy11</cite>.
-−
-A third family, arsenate reductase ([[Phosphatase_Family_ArsC|ArsC]]) <cite>Bennett</cite>, is only found in prokaryotes. While known to reduce arsenate to arsenite (a similar reaction to the phosphatase reaction), the B. subtilis gene also has in vitro phosphatase activity. A different phosphatase fold, CDC25/Rhodanese also has members in plants and yeast (ACR2) that are capable of arsenate reductase activity, highlighting the similarity of the protein phosphatase and arsenate reductase activities.
-−
-== Reference ==
-<biblio>
-#zhangy11 pmid=21204787
-#Bennett pmid=11698660
-</biblio>

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based II]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC2|Superfamily CC2]]
-This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]].
+This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_CC1|superfamily CC1]] and [[Phosphatase_Superfamily_CC2|superfamily CC2]].
 The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Despite having only 15% sequence identity, human LMWPTP and SSU72 structures superimpose with an rmsd of 1.7 Å <cite>zhangy11</cite>.

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based II]]
 This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]].

@@ Line 6: / Line 6: @@
 The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Despite having only 15% sequence identity, human LMWPTP and SSU72 structures superimpose with an rmsd of 1.7 Å <cite>zhangy11</cite>.
-A third family, arsenate reductase (ArsC) <cite>Bennett</cite>, is only found in prokaryotes. While known to reduce arsenate to arsenite (a similar reaction to the phosphatase reaction), the B. subtilis gene also has in vitro phosphatase activity. A different phosphatase fold, CDC25/Rhodanese also has members in plants and yeast (ACR2) that are capable of arsenate reductase activity, highlighting the similarity of the protein phosphatase and arsenate reductase activities.
+A third family, arsenate reductase ([[Phosphatase_Family_ArsC|ArsC]]) <cite>Bennett</cite>, is only found in prokaryotes. While known to reduce arsenate to arsenite (a similar reaction to the phosphatase reaction), the B. subtilis gene also has in vitro phosphatase activity. A different phosphatase fold, CDC25/Rhodanese also has members in plants and yeast (ACR2) that are capable of arsenate reductase activity, highlighting the similarity of the protein phosphatase and arsenate reductase activities.
 == Reference ==

← Older revision		Revision as of 23:35, 26 May 2014
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	__NOTOC__		__NOTOC__
−
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III\|Superfamily Cys-based III]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III\|Superfamily Cys-based III]]

@@ Line 3: / Line 3: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
-The superfamily share the common CX5R motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]]. Although the member families have very divergent sequences, they have similar fold to each other and all of them has CX5R motif.
+This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]].
-The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.
+The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very similar. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.
 The subfamily has an additional member only present in prokaryotes, arsenate reductase (ArsC). It has low sequence identity with LMWPTP and SSU72, 19% between Golden Staph ArsC (PDB ID: 1LJL) and mouse LMWPTP (PDB ID: 2P4U), 16% between Golden Staph ArsC and fruit fly SSU72 (PDB ID: 3FMV). But, ArsC has very similar structure with LMWPTP as shown in [http://scop.berkeley.edu/sunid=52789 SCOP database].

← Older revision		Revision as of 17:55, 30 April 2014
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	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III\|Superfamily Cys-based III]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III\|Superfamily Cys-based III]]
		+
		+	The superfamily share the common CX5R motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I\|Superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II\|Superfamily Cys-based II]]. Although the member families have very divergent sequences, they have similar fold to each other and all of them has CX5R motif.

	The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP\|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72\|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.		The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP\|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72\|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.