Phosphtase Subfamily CDC25 - Revision history

Gerard at 01:48, 23 August 2015

2015-08-23T01:48:19Z

Gerard at 06:42, 30 December 2014

2014-12-30T06:42:54Z

Gerard: Gerard moved page Subfamily CDC25 to Phosphtase Subfamily CDC25

2014-12-30T06:42:17Z

Gerard moved page Subfamily CDC25 to Phosphtase Subfamily CDC25

Gerard at 20:34, 6 December 2014

2014-12-06T20:34:12Z

Mark at 01:10, 16 June 2014

2014-06-16T01:10:46Z

Mark at 05:34, 28 May 2014

2014-05-28T05:34:18Z

Mark at 23:52, 27 May 2014

2014-05-27T23:52:05Z

Mark at 23:50, 27 May 2014

2014-05-27T23:50:46Z

Mark: /* References */

2014-05-27T19:51:16Z

‎References

Mark at 19:51, 27 May 2014

2014-05-27T19:51:06Z

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Phosphatse_Subfamily_CDC25|Subfamily CDC25]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhodanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Phosphatse_Subfamily_CDC25|Subfamily CDC25]]
 CDC25 subfamily has three member genes in human, '''[[Gene_CDC25A|CDC25A]]''', '''[[Gene_CDC25B|CDC25B]]''', '''[[Gene_CDC25C|CDC25C]]'''. They contain a catalytic domain on the C-terminus <cite>fauman98 reynolds99</cite>, and a less-conserved N-terminal regulatory region <cite>forrest01</cite>, which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers <cite>Boutros07</cite>.

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Subfamily_CDC25|Subamily CDC25]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Phosphatse_Subfamily_CDC25|Subfamily CDC25]]
 CDC25 subfamily has three member genes in human, '''[[Gene_CDC25A|CDC25A]]''', '''[[Gene_CDC25B|CDC25B]]''', '''[[Gene_CDC25C|CDC25C]]'''. They contain a catalytic domain on the C-terminus <cite>fauman98 reynolds99</cite>, and a less-conserved N-terminal regulatory region <cite>forrest01</cite>, which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers <cite>Boutros07</cite>.

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_II|Superfamily Cys-based III (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Subfamily_CDC25|Subamily CDC25]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Subfamily_CDC25|Subamily CDC25]]
 CDC25 subfamily has three member genes in human, '''[[Gene_CDC25A|CDC25A]]''', '''[[Gene_CDC25B|CDC25B]]''', '''[[Gene_CDC25C|CDC25C]]'''. They contain a catalytic domain on the C-terminus <cite>fauman98 reynolds99</cite>, and a less-conserved N-terminal regulatory region <cite>forrest01</cite>, which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers <cite>Boutros07</cite>.

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_II|Superfamily Cys-based II (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Subfamily_CDC25|Subamily CDC25]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_II|Superfamily Cys-based III (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Subfamily_CDC25|Subamily CDC25]]
 CDC25 subfamily has three member genes in human, '''[[Gene_CDC25A|CDC25A]]''', '''[[Gene_CDC25B|CDC25B]]''', '''[[Gene_CDC25C|CDC25C]]'''. They contain a catalytic domain on the C-terminus <cite>fauman98 reynolds99</cite>, and a less-conserved N-terminal regulatory region <cite>forrest01</cite>, which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers <cite>Boutros07</cite>.

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_II|Superfamily Cys-based II (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]: [[Subfamily_CDC25|Subamily CDC25]]
-CDC25 composes of a catalytic domain on the C-terminus <cite>fauman98 reynolds99</cite>, and a less-conserved N-terminal regulatory region <cite>forrest01</cite>, which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers <cite>Boutros07</cite>.
+CDC25 subfamily has three member genes in human, '''[[Gene_CDC25A|CDC25A]]''', '''[[Gene_CDC25B|CDC25B]]''', '''[[Gene_CDC25C|CDC25C]]'''. They contain a catalytic domain on the C-terminus <cite>fauman98 reynolds99</cite>, and a less-conserved N-terminal regulatory region <cite>forrest01</cite>, which can be phosphorylated and ubiquitinated. CDC25 activates cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]) by dephosphorylating two sites within their ATP binding loop. CDKs regulate key transitions between cell cycle phases, and are key components of the checkpoint pathways involved in DNA damage. Thus, it is not suppressing to find it overexpressed in many human cancers <cite>Boutros07</cite>.
 CDC25 is found in most animals, but is absent from land plants and green alga ''Chalmydomonas''.  In excavates, they are found in ''Trichomonas'', but not ''Giardia'', ''Leishmania'', or ''Trypanosomes''.
-== References ==
+==== References ====
 <biblio>
 #forrest01 pmid=11466620

← Older revision	Revision as of 06:42, 30 December 2014
(No difference)

@@ Line 12: / Line 12: @@
 #fauman98 pmid=9604936
 #Boutros07 pmid=17568790
 </biblio>