Technical Note PTPN14 - Revision history

Gerard at 03:31, 18 May 2016

2016-05-18T03:31:15Z

Gerard at 03:30, 18 May 2016

2016-05-18T03:30:57Z

Gerard: Created page with "NOTOC Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Subf..."

2016-05-18T03:29:59Z

Created page with "__NOTOC__ Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Subf..."

New page

__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN14|Subfamily PTPN14]]

====PTPN14 subfamily technical notes====
PTPN14 is generally poorly conserved between the FERM and phosphatase domains, but does have a number of motifs that are highly conserved between vertebrate members (PTPN14 and PTPN21) and invertebrate members. From N- to C-termini, these motifs are:

* P[st]YRp[ats]PDY[de].~
* SQPE~
* RPPY....sSTPdLa
* S[sn]PDLVS

Letters in square brackets are optional, lowercase is less conserved ~=small hydrophobic. Note the similarity between motifs 3 and 4.

Motif 3 includes a PPxY motif that interacts with WW domains, and is known to be involved in bindings the WW domains of KIBRA (WWC1) and YAP. A second PPxY motif is found in vertebrate and some invertebrate forms, with a consensus of PPxYPG.

← Older revision		Revision as of 03:31, 18 May 2016
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	Motif 3 includes a PPxY motif that interacts with WW domains, and is known to be involved in bindings the WW domains of KIBRA (WWC1) and YAP. A second PPxY motif is found in vertebrate and some invertebrate forms, with a consensus of PPxYPG.		Motif 3 includes a PPxY motif that interacts with WW domains, and is known to be involved in bindings the WW domains of KIBRA (WWC1) and YAP. A second PPxY motif is found in vertebrate and some invertebrate forms, with a consensus of PPxYPG.

−	[[User:Gerard\|Gerard]] ([[User talk:Gerard\|talk]]) 03:30, 18 May 2016 (UTC)	+	--
		+	[[User:Gerard\|Gerard]] ([[User talk:Gerard\|talk]]) 03:31, 18 May 2016 (UTC)

← Older revision		Revision as of 03:30, 18 May 2016
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	Motif 3 includes a PPxY motif that interacts with WW domains, and is known to be involved in bindings the WW domains of KIBRA (WWC1) and YAP. A second PPxY motif is found in vertebrate and some invertebrate forms, with a consensus of PPxYPG.		Motif 3 includes a PPxY motif that interacts with WW domains, and is known to be involved in bindings the WW domains of KIBRA (WWC1) and YAP. A second PPxY motif is found in vertebrate and some invertebrate forms, with a consensus of PPxYPG.
		+
		+	[[User:Gerard\|Gerard]] ([[User talk:Gerard\|talk]]) 03:30, 18 May 2016 (UTC)

Technical Note PTPN14 - Revision history

Gerard at 03:31, 18 May 2016

Gerard at 03:30, 18 May 2016

Gerard: Created page with "__NOTOC__ Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Subf..."

Gerard: Created page with "NOTOC Phosphatase Classification: Superfamily CC1: Family PTP: Phosphatase_Subf..."