Difference between revisions of "Phosphatase Subfamily FCP1"
From PhosphataseWiki
| Line 12: | Line 12: | ||
===Functions=== | ===Functions=== | ||
| + | FCP1 preferentially hydrolyzes Ser2 in CTD repeats in fission yeast <cite> Schwer15 </cite>. | ||
===== Substrates and Related Kinases ===== | ===== Substrates and Related Kinases ===== | ||
| Line 18: | Line 19: | ||
=== References === | === References === | ||
<biblio> | <biblio> | ||
| + | #hsin2014 pmid=24752900 | ||
#Kamenski04 pmid=15304220 | #Kamenski04 pmid=15304220 | ||
| + | #Schwer15 pmid=25883047 | ||
</biblio> | </biblio> | ||
=== Links === | === Links === | ||
[http://www.ncbi.nlm.nih.gov/gene/2221 Human FCP1] from NCBI Gene | [http://www.ncbi.nlm.nih.gov/gene/2221 Human FCP1] from NCBI Gene | ||
Revision as of 18:43, 18 April 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily FCP1
F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].
Evolution
FCP1 is conserved from yeast to human, usually one copy per genome.
Domain Structure
In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF.
Functions
FCP1 preferentially hydrolyzes Ser2 in CTD repeats in fission yeast [2].
Substrates and Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
Error fetching PMID 24752900:
Error fetching PMID 15304220:
Error fetching PMID 25883047:
Error fetching PMID 15304220:
Error fetching PMID 25883047:
- Error fetching PMID 15304220:
- Error fetching PMID 25883047:
- Error fetching PMID 24752900:
Links
Human FCP1 from NCBI Gene
