Difference between revisions of "Phosphatase Subfamily egg"
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=== Function === | === Function === | ||
| − | All three ''C. elegans'' members are predicted to be catalytically inactive, due to loss of the cysteine | + | All three ''C. elegans'' members are predicted to be catalytically inactive, due to loss of the cysteine or arginine of the Cx5R motif. The near-identical proteins, egg-4 and egg-5, control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>. |
=== References === | === References === | ||
Revision as of 21:20, 7 September 2016
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Egg
Evolution
The eak subfamily is nematode specific. C. elegans has three members: egg-3, egg-4, egg-5.
Domain
The egg subfamily has a single structural domain: the phosphatase domain of CC1 fold.
Function
All three C. elegans members are predicted to be catalytically inactive, due to loss of the cysteine or arginine of the Cx5R motif. The near-identical proteins, egg-4 and egg-5, control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling [1, 2, 3].
References
Error fetching PMID 19879842:
Error fetching PMID 19879147:
Error fetching PMID 19879835:
Error fetching PMID 19879147:
Error fetching PMID 19879835:
- Error fetching PMID 19879842:
- Error fetching PMID 19879147:
- Error fetching PMID 19879835:
