Phosphatase Subfamily PRL

Phosphatase Classification: Superfamily CC1: Family DSP: Subfamily PRL

PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers [1, 2]. PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants (unpublish data from gOrtholog). The molecular mechanisms of PRL phosphatases is reviewed at here [3] in 2012, but it may play other roles as more works are going-on (e.g. [1]).

Reference

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