Phosphatase Family MDP1

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Phosphatase Classification: Superfamily HAD: Family MDP1

This family typically has one member in unikonts (MDP1 in human), though it is lost from Drosophila and C. elegant. It has been reported as a putative tyrosine phosphatase [1]. However, a later study reported that it is a protein-fructosamine-6-phosphatase potentially involved in glycation repair [2]. This activity was 100-fold higher than it's tyrosine phosphatase activity, and MDP1 has not been shown to have activity on phosphopeptides [3].

References

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  1. Error fetching PMID 15461449: [Peisach04]
  2. Error fetching PMID 16670083: [Fortpied06]
  3. Error fetching PMID 10889041: [Selengut]
All Medline abstracts: PubMed | HubMed